Report error Found 3175 Enz. Inhib. hit(s) with Target = 'NACHT, LRR and PYD domains-containing protein 3'
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 1 hrs followed by ATP addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Hospital Universitario Santa Cristina
Curated by ChEMBL
Hospital Universitario Santa Cristina
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in ATP induced IL-1beta release pretreated for 15 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of NLRP3 in LPS/nigericin induced PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta production measured after 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as reduction in TNFalpha level preincubated for 0.5 hrs followed by LPS treatment for 3.5 hrs and fu...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Hospital Universitario Santa Cristina
Curated by ChEMBL
Hospital Universitario Santa Cristina
Curated by ChEMBL
Affinity DataIC50: 0.390nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in ATP induced IL-1beta release pretreated for 15 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated for 3 hrs followed by nigericin addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production measured after 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production measured after 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated for 3 hrs followed by nigericin addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated for 3 hrs followed by nigericin addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 15 mins followed by ATP/LPS addition measured ...More data for this Ligand-Target Pair
Affinity DataKd: 0.532nMAssay Description:Binding affinity to NLRP3 (unknown origin) expressed in HEK293T cells incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.560nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated for 3 hrs followed by nigericin addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated for 3 hrs followed by nigericin addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated for 3 hrs followed by nigericin addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.620nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 1 hrs followed by nigericin addition measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as reduction in Il-1beta production preincubated for 0.5 hrs followed by LPS treatment for 3.5 hrs a...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production measured after 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.843nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as reduction in Il-1beta production preincubated for 0.5 hrs followed by LPS treatment for 3.5 hrs a...More data for this Ligand-Target Pair
Affinity DataKd: 0.860nMAssay Description:Binding affinity to human recombinant NLRP3 inflammasomeMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataKd: 0.980nMAssay Description:Binding affinity to human recombinant NLRP3 inflammasomeMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 1 hrs followed by nigericin addition measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 1 hrs followed by nigericin addition measured ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Hospital Universitario Santa Cristina
Curated by ChEMBL
Hospital Universitario Santa Cristina
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assessed as reduction in IL-1beta level preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Hospital Universitario Santa Cristina
Curated by ChEMBL
Hospital Universitario Santa Cristina
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta level incubated for 1 hr followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as reduction in Il-1beta production preincubated for 0.5 hrs followed by LPS treatment for 3.5 hrs a...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as reduction in IL-1beta production measured after 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated on the basis of the inhibitory activity of the IL-1β production in THP1-N...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-induced human THP-1 cells expressing GFP-tagged ASC assessed as disruption of ASC speck formation ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of NLRP3 in LPS/nigericin induced human THP-1 cells assessed as reduction in pyroptosis pretreated for 3 hrs in presence of LPS followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated on the basis of the inhibitory activity of the IL-1β production in THP1-N...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated on the basis of the inhibitory activity of the IL-1β production in T...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 2.60nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated on the basis of the inhibitory activity of the IL-1β production in T...More data for this Ligand-Target Pair
Ligand InfoSimilars













3D Structure (crystal)































