Compile Data Set for Download or QSAR
Report error Found 137 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-2/beta-2'
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100707((R)-2-(6-Fluoro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Affinity DataKi:  0.00200nMAssay Description:Binding affinity towards rat alpha2-beta2 neuronal nAChR expressed in Xenopus oocytes using [3H]epibatidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity towards rat alpha2-beta2 neuronal nAChR expressed in Xenopus oocytes using [3H]epibatidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100715(2-(6-Bromo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity towards rat alpha2-beta2 neuronal nAChR expressed in Xenopus oocytes using [3H]epibatidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKd:  0.0200nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]epibatidine from rat alpha-2-beta-2 nACHR expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0250nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0250nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0250nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0260nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0260nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0280nMAssay Description:Binding affinity towards rat alpha2-beta2 neuronal nAChR expressed in Xenopus oocytes using [3H]epibatidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143281(3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine | CHEMBL5...)
Affinity DataKi:  0.0310nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475411(CHEMBL197830)
Affinity DataKi:  0.0350nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50106490(2-(6-Chloro-5-phenyl-pyridin-3-yl)-7-aza-bicyclo[2...)
Affinity DataKi:  0.0370nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475410(CHEMBL372133)
Affinity DataKi:  0.0400nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475409(CHEMBL197526)
Affinity DataKi:  0.0440nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475407(CHEMBL198228)
Affinity DataKi:  0.0530nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100713(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ylamin...)
Affinity DataKi:  0.0620nMAssay Description:Binding affinity towards rat alpha2-beta2 neuronal nAChR expressed in Xenopus oocytes using [3H]epibatidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM86816(NSC_45263769 | CAS_45263769 | rac-2-(5-(4-chloroph...)
Affinity DataKi:  0.0640nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50171007(4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyri...)
Affinity DataKi:  0.0660nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50049750(CHEMBL59986 | (S)-3-(azetidin-2-ylmethoxy)pyridine...)
Affinity DataKi:  0.0740nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM86815(CAS_45266019 | NSC_45266019 | rac-2-(6-fluoro-5-(4...)
Affinity DataKi:  0.0790nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM397477(US9993465, Sazetidine-A)
Affinity DataKi:  0.0870nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataKi:  0.0870nM ΔG°:  -53.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475406(CHEMBL372326)
Affinity DataKi:  0.245nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50210335(CHEMBL3898434)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50210334(CHEMBL3948977)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50216347((1S,4S)-2-(3-pyridinyl)-2,5-diazabicyclo[2.2.1]hep...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM221048(US9303017, Varenicline | US9284322, varenicline)
Affinity DataKi:  0.480nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50166908(CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...)
Affinity DataKi:  0.480nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50106488(2-(6-Fluoro-5-phenyl-pyridin-3-yl)-7-aza-bicyclo[2...)
Affinity DataKi:  0.643nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475816(CHEMBL205644)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]epibatidine from rat alpha-2-beta-2 nACHR expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50170586((3S)-3-{[(2S)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2...)
Affinity DataIC50: 0.75nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta2; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50210337(CHEMBL3970672)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143282((1R,9R)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]epibatidine from rat alpha-2-beta-2 nACHR expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475408(CHEMBL382533)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143282((1R,9R)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475405(CHEMBL197725)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity towards rat Nicotinic acetylcholine receptor alpha2-beta2 using 0.5 nM [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM50170592(CHEMBL411146)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta2; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50452056(CHEMBL417586)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50210338(CHEMBL3926480)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50452054(CHEMBL53620)
Affinity DataKi:  3.10nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)
Affinity DataKi:  5.30nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM397483(US9993465, (S)-17)
Affinity DataKi:  5.30nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50452053(CHEMBL55732)
Affinity DataKi:  5.5nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Human)
Georgetown University

US Patent
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]epibatidine from alpha2beta2 nAChR after 4 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50452055(CHEMBL56045)
Affinity DataKi:  7.5nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50475815(CHEMBL379303)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]epibatidine from rat alpha-2-beta-2 nACHR expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)
Affinity DataKi:  8.60nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

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