Compile Data Set for Download or QSAR
Report error Found 1847 Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 1'
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50091652(PYY | CHEMBL269503 | PYY, rat | Peptide YY(PYY)(YP...)
Affinity DataIC50: 0.0200nMAssay Description:Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0260nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553107(CHEMBL4746035)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Guinea pig)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM84999(PYY,[leu31,Pro34], human)
Affinity DataKi:  0.0350nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Guinea pig)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM82276(NPY [Leu31, Pro34], human | NPY,[leu31,Pro34], por...)
Affinity DataKi:  0.0350nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.0370nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50240829(CHEMBL3559801)
Affinity DataEC50:  0.0398nMAssay Description:Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Gal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0400nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Guinea pig)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM50005530(Tyr-Pro-Ser-Lys-Pro-Asp-Asn-pro-Gly-Glu-Asp-Ala-Pr...)
Affinity DataKi:  0.0430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0440nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0480nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Guinea pig)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM82421(CAS_81858-94-8 | PYY, porcine)
Affinity DataKi:  0.0480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50075807(1-(3-{1-[2-(4-Iodo-phenyl)-ethyl]-piperidin-4-yl}-...)
Affinity DataKi:  0.0520nMAssay Description:Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553110(CHEMBL4794692)
Affinity DataKi:  0.0525nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553107(CHEMBL4746035)
Affinity DataIC50: 0.0550nMAssay Description:Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553104(CHEMBL4743976)
Affinity DataKi:  0.0589nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Rat)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM50005530(Tyr-Pro-Ser-Lys-Pro-Asp-Asn-pro-Gly-Glu-Asp-Ala-Pr...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Rat)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM82276(NPY [Leu31, Pro34], human | NPY,[leu31,Pro34], por...)
Affinity DataKi:  0.0610nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553111(CHEMBL4786911)
Affinity DataIC50: 0.0617nMAssay Description:Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553105(CHEMBL4762668)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.0631nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Guinea pig)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM85534(NPY, zebrafish)
Affinity DataKi:  0.0660nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553117(CHEMBL4755692)
Affinity DataIC50: 0.0661nMAssay Description:Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553108(CHEMBL4743858)
Affinity DataKi:  0.0676nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50409214(GR-231118 | CHEMBL2110365)
Affinity DataKi:  0.0700nMAssay Description:Affinity for cloned Y1 receptor using [125I]PYY as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM82288(NPY, porcine | NPY26-36, porcine)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553109(CHEMBL4751322)
Affinity DataKi:  0.0708nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0740nMAssay Description:Binding affinity to NPY1R in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553106(CHEMBL4752392)
Affinity DataKi:  0.0741nMAssay Description:Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataKi:  0.0770nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553110(CHEMBL4794692)
Affinity DataIC50: 0.0794nMAssay Description:Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0830nMAssay Description:Binding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50005530(Tyr-Pro-Ser-Lys-Pro-Asp-Asn-pro-Gly-Glu-Asp-Ala-Pr...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50553113(CHEMBL4798118)
Affinity DataIC50: 0.0912nMAssay Description:Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataKi:  0.0960nMAssay Description:Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Rat)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM85534(NPY, zebrafish)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50466532(CHEMBL4281479)
Affinity DataEC50:  0.100nMAssay Description:Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50466532(CHEMBL4281479)
Affinity DataEC50:  0.100nMAssay Description:Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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