Compile Data Set for Download or QSAR
Report error Found 1304 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4-kinase'
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448085(CHEMBL3121323)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448094(CHEMBL3121314)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200009(CHEMBL3923414)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448089(CHEMBL3121319)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107257(CHEMBL3600785)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448086(CHEMBL3121322)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448096(CHEMBL3121334)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448103(CHEMBL3121327)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107256(CHEMBL3600784)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200098(CHEMBL3930509)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448090(CHEMBL3121318)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200106(CHEMBL3936684)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to 6xHisGB1 tagged PI4KB (unknown origin) expressed in Escherichia coli BL21 Star by fluorescence anisotropy based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50649205(CHEMBL5618321)
Affinity DataIC50: 4nMAssay Description:Inhibition of Phosphatidylinositol 4-Kinase III beta (unknown origin) preincubated for 10 min followed by incubated with ATP for 1 hr by ADP-Glo kina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457886(CHEMBL4211696)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50649203(CHEMBL5619521)
Affinity DataIC50: 4nMAssay Description:Inhibition of Phosphatidylinositol 4-Kinase III beta (unknown origin) preincubated for 10 min followed by incubated with ATP for 1 hr by ADP-Glo kina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448088(CHEMBL3121320)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107248(CHEMBL3600781)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457855(CHEMBL4211181)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448097(CHEMBL3121333)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457854(CHEMBL4206816)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448077(CHEMBL3121308)
Affinity DataIC50: 5.01nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200012(CHEMBL3958915)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50492527(CHEMBL2407818)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant PI4K3beta (unknown origin) using PI:PS as substrate after 75 to 90 mins by scintillation counting analysis in presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50492527(CHEMBL2407818)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of PI4KIIIbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50595930(CHEMBL5188324)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PI4KIIIbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200109(CHEMBL3974986)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to 6xHisGB1 tagged PI4KB (unknown origin) expressed in Escherichia coli BL21 Star by fluorescence anisotropy based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199891(CHEMBL3920652)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107243(CHEMBL3600779)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448084(CHEMBL3121324)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457848(CHEMBL4215244)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457867(CHEMBL4203566)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200000(CHEMBL3911522)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50107254(CHEMBL3600782)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457850(CHEMBL4203041)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457868(CHEMBL4202450)
Affinity DataIC50: 8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457876(CHEMBL4209793)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Affinity DataIC50: 8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50005005(CHEMBL2397317)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200097(CHEMBL3939697)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199889(CHEMBL3957128)
Affinity DataIC50: 9nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457860(CHEMBL4207851)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM735437(US20250129103, Compound 19)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50S for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

LigandPNGBDBM735436(US20250129103, Compound 18)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50S for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

LigandPNGBDBM735435(US20250129103, Compound 17)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50S for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

LigandPNGBDBM735605(US20250129103, Compound 192)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50S for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

LigandPNGBDBM735604(US20250129103, Compound 191)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50S for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

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