Compile Data Set for Download or QSAR
Report error Found 624 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily KQT member 2/3'
LigandPNGBDBM50420073(CHEMBL2047506)
Affinity DataEC50:  10nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50592356(CHEMBL4458793)
Affinity DataEC50:  18nMAssay Description:Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50465779(CHEMBL4278049)
Affinity DataEC50:  20nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50415511(CHEMBL598553)
Affinity DataEC50:  21nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415531(CHEMBL592297)
Affinity DataEC50:  23nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50121052(CHEMBL3621438)
Affinity DataEC50:  24nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50415509(CHEMBL599164)
Affinity DataEC50:  25nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415502(CHEMBL598126)
Affinity DataEC50:  27nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415507(CHEMBL604937)
Affinity DataEC50:  28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415516(CHEMBL599374)
Affinity DataEC50:  28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415529(CHEMBL589898)
Affinity DataEC50:  29nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50420077(CHEMBL2047511)
Affinity DataEC50:  30nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50120996(CHEMBL3621449)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50465781(CHEMBL4276984)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50465775(CHEMBL1703636)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50415521(CHEMBL609624)
Affinity DataEC50:  44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415526(CHEMBL591302)
Affinity DataEC50:  44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415520(CHEMBL599376)
Affinity DataEC50:  49nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50513737(CHEMBL4549421)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513734(CHEMBL4516269)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50121053(CHEMBL3621439)
Affinity DataEC50:  50nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50465773(CHEMBL4277250)
Affinity DataEC50:  50nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50415506(CHEMBL599781)
Affinity DataEC50:  53nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50595542(CHEMBL5204124)
Affinity DataEC50:  60nMAssay Description:Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell pat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50339281(5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(...)
Affinity DataEC50:  60nMAssay Description:Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50415517(CHEMBL599375)
Affinity DataEC50:  62nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50121054(CHEMBL3621440)
Affinity DataEC50:  62nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50121055(CHEMBL3621441)
Affinity DataEC50:  64nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50513733(CHEMBL4460237)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513725(CHEMBL4584469)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50420079(CHEMBL2047513)
Affinity DataEC50:  70nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50465772(CHEMBL4288317)
Affinity DataEC50:  80nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50465782(CHEMBL4280414)
Affinity DataEC50:  80nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50513740(CHEMBL4455848)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50420063(CHEMBL2046680)
Affinity DataEC50:  80nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50420078(CHEMBL2047512)
Affinity DataEC50:  80nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50415504(CHEMBL596909)
Affinity DataEC50:  91nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415530(CHEMBL602305)
Affinity DataEC50:  95nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415510(CHEMBL591203)
Affinity DataEC50:  98nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50415525(CHEMBL589667)
Affinity DataEC50:  100nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50465774(CHEMBL4287894)
Affinity DataEC50:  100nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50485659(CHEMBL2147030)
Affinity DataEC50: <100nMAssay Description:Activation of KCNQ2/Q3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
LigandPNGBDBM50121056(CHEMBL3621442)
Affinity DataEC50:  110nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50420082(CHEMBL2047516)
Affinity DataEC50:  110nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50395464(CHEMBL2164048)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at KCNQ2/Q3 expressed in CHO cells incubated for 3 mins by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50513732(CHEMBL4448080)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50465777(CHEMBL4288707)
Affinity DataEC50:  130nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50513738(CHEMBL4473937)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
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