Compile Data Set for Download or QSAR
Report error Found 1038 Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 3'
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human RIP3 kinase activity by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50511306(CHEMBL4470115)
Affinity DataIC50: 0.300nMAssay Description:Displacement of fluorescein labeled probe from full length human GST-tagged RIPK3 expressed in Sf9 cells incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human RIP3 kinase domain (1 to 328 residues) expressed in baculovirus expression system by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human RIP3 kinase activity by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50621578(CHEMBL5407694)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to human RIPK3 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST tagged recombinant RIPK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of his tagged recombinant RIPK3 (unknown origin) incubated for 4 hrs by ADP-glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant GST-tagged RIPK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human RIP3 kinase domain (1 to 328 residues) expressed in baculovirus expression system by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50428286(GSK2118436A | DABRAFENIB)
Affinity DataIC50: 2nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50511307(CHEMBL4455682)
Affinity DataIC50: 2.90nMAssay Description:Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519648(CHEMBL4441118)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human RIP3 kinase activity by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519648(CHEMBL4441118)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to human wild type RIPK3 (M1/Q307) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50511302(CHEMBL4476485)
Affinity DataIC50: 8nMAssay Description:Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519648(CHEMBL4441118)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519648(CHEMBL4441118)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of recombinant human RIP3 kinase domain (1 to 328 residues) expressed in baculovirus expression system by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant RIPK3 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins in p...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519646(CHEMBL4464634)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST tagged recombinant RIPK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50651042(CHEMBL5629959)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant RIPK3 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins in p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50511310(CHEMBL4552106)
Affinity DataIC50: 16nMAssay Description:Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50184765(CHEMBL3823499)
Affinity DataIC50: 16nMAssay Description:Inhibition of RIPK3 (unknown origin) preincubated for 10 mins followed by addition of fluorescent-labeled 2-Methyl-5-(2-propen-l-yloxy)aniline measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant RIPK3 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50323777(N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylami...)
Affinity DataIC50: 19nMAssay Description:Inhibition of RIPK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50651043(CHEMBL5632140)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant RIPK3 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins in p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50246489(CHEMBL4091441)
Affinity DataEC50:  21nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392953(US10301306, Example 151)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392942(US10301306, Example 140)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392940(US10301306, Example 138)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392939(US10301306, Example 137)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392816(5-Fluoro-2-((4-oxo-2-(pyridin-4-yl)-3-(thiophen-2-...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392816(5-Fluoro-2-((4-oxo-2-(pyridin-4-yl)-3-(thiophen-2-...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392944(US10301306, Example 142)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392815(3-(4-Fluorophenyl)-1-(4-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392943(US10301306, Example 141)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392966(US10301306, Example 164)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392836(US10301306, Example 34)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392902(US10301306, Example 161 | US10301306, Example 100)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392840(US10301306, Example 38)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392958(N-(4-(1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392829(US10301306, Example 27)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392955(3-(4-Fluorophenyl)-7,7-dimethyl-2-(pyridin-4-yl)-6...)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392962(US10301306, Example 160)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM392961(US10301306, Example 159)
Affinity DataIC50: 30nMAssay Description:The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

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