Compile Data Set for Download or QSAR
Report error Found 672 Enz. Inhib. hit(s) with Target = 'Ribonucleoside-diphosphate reductase large subunit'
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053967((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033458((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-(2-Benzyl-3-phen...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033457(1-[(S)-((S)-1-Carboxy-3-methyl-butylcarbamoyl)-((S...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50369164(CHEMBL1169533)
Affinity DataIC50: 2nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50369164(CHEMBL1169533)
Affinity DataIC50: 2nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050831((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50: 3nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053968((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50: 3nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050831((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033463((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3,3-dimethyl-2-...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050824((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[(1-ethyl-pro...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053981((S)-2-((S)-3-Carboxy-2-{(2R,5S)-2-(3,3-dimethyl-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033465((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[(S)...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053973((S)-3-((S)-2-{(S)-2-[3-(1-Ethyl-propyl)-ureido]-3,...)
Affinity DataIC50: 6nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033453(1-((S)-((S)-1-Carboxy-3-methyl-butylcarbamoyl)-{(S...)
Affinity DataIC50: 6.40nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053984((S)-2-{(S)-3-Carboxy-2-[(2S,5S)-5-[3-(1-ethyl-prop...)
Affinity DataIC50: 7nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050828((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[3-(...)
Affinity DataIC50: 7nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050828((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[3-(...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033470((S)-2-{(S)-3-Carboxy-2-[(S)-2-((S)-3-methyl-2-{(S)...)
Affinity DataIC50: 7.5nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050822((S)-2-{(S)-3-Carboxy-2-[(1-{(S)-2-[3-(1-ethyl-prop...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050826((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50: 15nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050826((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053962((S)-N-((R)-1-Ethyl-2,2-dimethyl-propyl)-3-((S)-2-{...)
Affinity DataIC50: 18nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477482(US10889555, Example 250 | 5-bromo-2-(N-((1S,2R)-2-...)
Affinity DataIC50: 20nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50369165(CHEMBL1169532)
Affinity DataIC50: 20nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033456((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[(S)-2-cycloh...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033477((S)-2-{(S)-2-[(S)-2-((S)-2-{(S)-2-[(2-Benzyl-3-phe...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033462((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[(S)...)
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033462((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[(S)...)
Affinity DataIC50: 24nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033462((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[(S)...)
Affinity DataIC50: 24nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053963((S)-3-((S)-2-{(S)-2-[3-(1-Ethyl-propyl)-ureido]-3,...)
Affinity DataIC50: 27nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477358(US10889555, Example 117 | 6-(8-oxa-3-azabicyclo[3....)
Affinity DataIC50: 30nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

LigandPNGBDBM754085(US12344588, Example 5A)
Affinity DataIC50: 30nMAssay Description:For measuring the inhibitory activity of the test compound against the RNR reaction, the method described in Cancer Research 64, 1-6 (2004) was refer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM601172(US11634395, Example 200B | US11634395, Example 207...)
Affinity DataIC50: 30nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM757084(US20250223270, Example 5A)
Affinity DataIC50: 30nMAssay Description:First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050821((S)-2-((S)-3-Carboxy-2-{[1-{(S)-2-[3-(1-ethyl-prop...)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050821((S)-2-((S)-3-Carboxy-2-{[1-{(S)-2-[3-(1-ethyl-prop...)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033461((S)-N-((S)-1-Hydroxymethyl-3,3-dimethyl-butyl)-3-(...)
Affinity DataIC50: 34nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(HHV-1)
Bio-MéGa/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050833((S)-2-[(S)-3-Carboxy-2-(2-{(S)-2-[3-(1-ethyl-propy...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033449((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[(S)-3,3-dime...)
Affinity DataIC50: 36nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477305(US10889555, Example 39 | US11634395, Example 39)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477477(US10889555, Example 245 | US11634395, Example 245)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053987((S)-N-(2,2-Dimethyl-propyl)-3-((S)-2-{(S)-2-[3-(1-...)
Affinity DataIC50: 40nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50033455(2-(3-Carboxy-2-{2-[2-(2-ethyl-butyrylamino)-3,3-di...)
Affinity DataIC50: 43nMAssay Description:In vitro inhibitory activity against HSV ribonucleotide reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM601200(5-fluoro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477519(US10889555, Example 287 | US11634395, Example 287)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477471(US10889555, Example 241 | 5-fluoro-N-((1S,2R)-2-(6...)
Affinity DataIC50: 50nMAssay Description:First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM601197(US11634395, Example 222B | US11634395, Example 226...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

LigandPNGBDBM477459(US10889555, Example 230B | US11634395, Example 230...)
Affinity DataIC50: 50nMAssay Description:For measuring the inhibitory activity of the test compound against the RNR reaction, the method described in Cancer Research 64, 1-6 (2004) was refer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477459(US10889555, Example 230B | US11634395, Example 230...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM477414(US10889555, Example 197 | 2-(N-((1S,2R)-2-(6-fluor...)
Affinity DataIC50: 60nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

Displayed 1 to 50 (of 672 total ) | Next | Last >>
Jump to: