Compile Data Set for Download or QSAR
Report error Found 164 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase NLK'
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human NLK incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50341342(6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-...)
Affinity DataKd:  6nMAssay Description:Inhibition of NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human NLK using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  16nMAssay Description:Binding affinity to human NLK incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  25nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  25nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  25nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13531(4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-...)
Affinity DataKd:  28nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13531(4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-...)
Affinity DataKd:  28nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537131(CHEMBL4575895)
Affinity DataKd:  28nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537134(CHEMBL4585158)
Affinity DataKd:  29nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  35nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50613196(CHEMBL5276374)
Affinity DataIC50: 41nMAssay Description:Inhibition of human NLK preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 55.5nMAssay Description:Inhibition of human NLK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 77.8nMAssay Description:Inhibition of human NLK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  160nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  160nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  160nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  160nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  170nMAssay Description:Inhibition of NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  170nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  170nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  220nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  220nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  220nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 250nMAssay Description:Inhibition of human NLK by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  260nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  260nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  260nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 336nMAssay Description:Inhibition of NLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537132(CHEMBL530635 | TCMDC-138886)
Affinity DataKd:  350nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6511(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4...)
Affinity DataKd:  410nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6511(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4...)
Affinity DataKd:  410nMAssay Description:Binding affinity to wild-type human full length NLK expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  480nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)
Affinity DataKd:  520nMAssay Description:Binding affinity to wild-type human full length NLK expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)
Affinity DataKd:  520nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  640nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  640nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  640nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  640nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537136(CHEMBL4556662)
Affinity DataKd:  650nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537133(CHEMBL4517424)
Affinity DataKd:  660nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524289(TCMDC-138471 | CHEMBL535429)
Affinity DataKd:  690nMAssay Description:Binding affinity to wild-type human full length NLK expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537130(CHEMBL4586530)
Affinity DataKd:  700nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  770nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  770nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524289(TCMDC-138471 | CHEMBL535429)
Affinity DataKd:  790nMAssay Description:Binding affinity to biotinylated full length human NLK expressed in Escherichia coli incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human wild type NLK using RBER-GSK3(14-27) as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  1.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase NLK(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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