Compile Data Set for Download or QSAR
Report error Found 3874 Enz. Inhib. hit(s) with Target = 'Serine protease 1'
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.00800nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of bovine beta-trypsin using Boc-QAR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50452161(CHEMBL4217607)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of bovine beta-trypsin incubated for 5 mins using BAPNA as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50452160(CHEMBL4217569)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of bovine beta-trypsin incubated for 5 mins using BAPNA as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50452159(CHEMBL4210529)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of bovine beta-trypsin incubated for 5 mins using BAPNA as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50452158(CHEMBL1801042)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of bovine beta-trypsin incubated for 5 mins using BAPNA as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50452162(CHEMBL4212172)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of bovine beta-trypsin incubated for 5 mins using BAPNA as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50452156(CHEMBL4211294)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of bovine beta-trypsin incubated for 5 mins using BAPNA as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076227((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.0270nMAssay Description:Inhibitory concentration against trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of human cationic trypsin using Boc-VPR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 0.0450nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0450nMAssay Description:Compound was tested in vitro for inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50069922(Boropeptide analogue | CHEMBL102069)
Affinity DataKi:  0.0450nMAssay Description:Tested for selectivity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50449678(CHEMBL4164510)
Affinity DataKi:  0.0460nMAssay Description:Inhibition of bovine beta-trypsin using Boc-QAR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034581(Peptide boronate | CHEMBL36744)
Affinity DataKi:  0.0540nMAssay Description:Binding affinity against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109663(US8609715, A-71)
Affinity DataKi:  0.0540nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50449677(CHEMBL4172393)
Affinity DataKi:  0.0620nMAssay Description:Inhibition of bovine beta-trypsin using Boc-QAR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076224((1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]...)
Affinity DataKi:  0.0730nMAssay Description:Inhibitory concentration against trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234238(US9346821, A-6)
Affinity DataKi:  0.0800nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50502661(CHEMBL4531752)
Affinity DataKi: <0.100nMAssay Description:Inhibition of bovine beta-trypsin using L-BAPNA as substrate preincubated for 5 mins followed by substrate addition and measured for 60 mins by color...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50520068(CHEMBL4447828)
Affinity DataKi: <0.100nMAssay Description:Inhibition of bovine beta-trypsin using L-BAPNA as substrate preincubated for 5 mins followed by substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi:  0.100nMAssay Description:Inhibition of bovine beta-trypsin type-3 using L-BAPNA as substrate preincubated for 5 mins followed by substrate addition measured over 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2019
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50289586(3-Methyl-2'-sulfamoyl-biphenyl-4-carboxylic acid [...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109651(US8609715, A-59)
Affinity DataKi:  0.120nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034585(Peptide boronate | CHEMBL285285)
Affinity DataKi:  0.150nMAssay Description:Binding affinity against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109630(US8609715, B-21)
Affinity DataKi:  0.150nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50449679(CHEMBL4167071)
Affinity DataKi:  0.170nMAssay Description:Inhibition of bovine beta-trypsin using Boc-QAR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193290(US9199927, 1)
Affinity DataIC50: 0.170nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193360(US9199927, 71)
Affinity DataIC50: 0.180nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158146(US9024044, 74 | US9227949, 74 | US9655879, 74)
Affinity DataKi:  0.180nMAssay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109692(US8609715, B-49)
Affinity DataKi:  0.180nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158146(US9024044, 74 | US9227949, 74 | US9655879, 74)
Affinity DataKi:  0.180nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 uL) was mixed with 20 uM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 uL) mixed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109629(US8609715, B-20)
Affinity DataKi:  0.180nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158146(US9024044, 74 | US9227949, 74 | US9655879, 74)
Affinity DataKi:  0.180nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL) was mixed with 20 μM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109668(US8609715, B-25)
Affinity DataKi:  0.190nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234247(US9346821, B-14)
Affinity DataKi:  0.190nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193349(US9199927, 108 | US9199927, 60)
Affinity DataIC50: 0.190nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193304(US9199927, 15)
Affinity DataIC50: 0.200nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109659(US8609715, A-67)
Affinity DataKi:  0.200nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109710(US8609715, C-4)
Affinity DataKi:  0.200nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109684(US8609715, B-41)
Affinity DataKi:  0.210nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158140(US9024044, 68 | US9227949, 68 | US9655879, 68)
Affinity DataKi:  0.210nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL) was mixed with 20 μM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193313(US9199927, 24)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193369(US9199927, 80)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234250(US9346821, B-20)
Affinity DataKi:  0.210nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158140(US9024044, 68 | US9227949, 68 | US9655879, 68)
Affinity DataKi:  0.210nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 uL) was mixed with 20 uM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 uL) mixed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193349(US9199927, 108 | US9199927, 60)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

Displayed 1 to 50 (of 3874 total ) | Next | Last >>
Jump to: