Compile Data Set for Download or QSAR
Report error Found 218 Enz. Inhib. hit(s) with Target = 'Solute carrier family 22 member 6'
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350468(CEFAMANDOLE)
Affinity DataKi:  30nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50206441(2-(2,4,5,7-tetrabromo-3-hydroxy-6-oxo-6H-xanthen-9...)
Affinity DataKi:  89nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50370587(CEFAZOLIN)
Affinity DataKi:  180nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50390999(CEFOPERAZONE)
Affinity DataKi:  210nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM82898(SMR000386987 | MLS001048966 | (6R,7R)-3-(acetyloxy...)
Affinity DataKi:  220nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50049707((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...)
Affinity DataKi:  230nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM4078(Elagic Acid | CHEMBL6246 | 6,7,13,14-tetrahydroxy-...)
Affinity DataIC50: 270nMAssay Description:TP_TRANSPORTER: inhibition of ochratoxin A uptake (ochratoxin A / 1uM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50485601(CHEMBL2075007)
Affinity DataKi:  400nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50270022(hexanedioic acid, ion(2-) | hexanedioate | adipate...)
Affinity DataKi:  410nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-benzoylphenyl)propanoic acid | 2-(3-Benzoylph...)
Affinity DataIC50: 500nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350473(Aliporina | CEFALORIDINE)
Affinity DataKi:  740nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 850nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50485602(CHEMBL2075010)
Affinity DataKi:  1.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-benzoylphenyl)propanoic acid | 2-(3-Benzoylph...)
Affinity DataIC50: 1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-benzoylphenyl)propanoic acid | 2-(3-Benzoylph...)
Affinity DataIC50: 1.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50074922(2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | ...)
Affinity DataIC50: 1.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataKi:  1.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50485603(CHEBI:7426 | CHEMBL2074738)
Affinity DataKi:  1.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataKi:  2.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of OAT1 (unknown origin) transfected in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by 6-CFL add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50420231(CHEMBL2074600)
Affinity DataKi:  2.74E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50143424(2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid | ...)
Affinity DataKi:  2.95E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50133599(CHEMBL119625 | YM-872 | (7-Imidazol-1-yl-6-nitro-2...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human OAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 3.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50335523(Claforan | Kefotex | cefotaxim | cefotaxime | (6R,...)
Affinity DataKi:  3.13E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM35847(DINOPROSTONE | [3H]Prostaglandin E2 | prostaglandi...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataKi:  3.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537496(CHEMBL4527448)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataIC50: 4.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataKi:  4.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataKi:  4.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50537500(CHEMBL4562825)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataKi:  4.41E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 4.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM) in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50485550(CHEBI:17859 | Glutarate)
Affinity DataIC50: 4.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50485608(CHEBI:28837 | Caprylic acid | EDENOR C 8-98-100 | ...)
Affinity DataKi:  5.41E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of Rochester School of Medicine and Dentistry

Curated by ChEMBL
LigandPNGBDBM25903(Fordiuran | Burinex | cid_2471 | 3-(butylamino)-4-...)
Affinity DataKi:  5.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 5.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50344964(Betamipron | N-(phenylcarbonyl)-beta-alanine | CHE...)
Affinity DataIC50: 6.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50270006(2-(4-aminobenzamido)acetate | AMINOHIPPURATE)
Affinity DataKi:  6.02E+3nMAssay Description:Inhibition of human Oat1 expressed in Drosophila S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50240008(CHEBI:104011 | Aminohippuric Acid | PAHA | Para-Am...)
Affinity DataKi:  6.02E+3nMAssay Description:TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50350467(BL-S578 | Cefadrops | CEFADROXIL)
Affinity DataKi:  6.14E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50637872(CHEMBL5542977)
Affinity DataIC50: 6.19E+3nMAssay Description:Inhibition of human OAT1 expressed in MDCK-II cells using 6-carboxyfluorescein as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataIC50: 6.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50269998((S)-2-((R)-5-chloro-8-hydroxy-3-methyl-1-oxoisochr...)
Affinity DataKi:  6.31E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataKi:  6.31E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataIC50: 6.51E+3nMAssay Description:Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 6(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50270021(glutarate(2-) | pentanedioate | glutarate)
Affinity DataKi:  6.70E+3nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Kyorin University

Curated by ChEMBL
LigandPNGBDBM50538736(CHEMBL4640580)
Affinity DataKi:  7.20E+3nMAssay Description:Inhibition of human OAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
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