Compile Data Set for Download or QSAR
Report error Found 933 Enz. Inhib. hit(s) with Target = 'TRAF2 and NCK-interacting protein kinase'
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549671(CHEMBL4760558)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549681(CHEMBL4749291)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549672(CHEMBL4762464)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549680(CHEMBL4759123)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549674(CHEMBL4751494)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549670(CHEMBL4744045)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549669(CHEMBL4788976)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549668(CHEMBL4788405)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549675(CHEMBL4797452)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549673(CHEMBL4791330)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549664(CHEMBL4756005)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.314nMAssay Description:Inhibition of human TNIK using RLGRDKYKTLRQIRQ as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549666(CHEMBL4788688)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549679(CHEMBL4760435)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM420217(US10485800, Cmpd ID FS | US10485800, Example 173)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549667(CHEMBL4797770)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.551nMAssay Description:Inhibition of human TNIK using RLGRDKYKTLRQIRQ as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50550593(CHEMBL4746566)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of TNIK (unknown origin) in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549663(CHEMBL4780310)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50192349(9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549665(CHEMBL4781043)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50549688(CHEMBL4743105)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579718(US11485711, Compound 146 | 3-ethyl-4-((5-(4-iodoph...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579738(US11485711, Compound 180 | N-(4-((5-(4-(1H-pyrazol...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579704(US11485711, Compound 109 | N-(4-((5-(4-(1H-imidazo...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579709(US11485711, Compound 119 | 4-((5-(5-chlorothiophen...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM571666(5-((5-(3-fluoro-4- hydroxyphenyl)-1H- pyrazol-3- y...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11447469-20220920-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM571674(6-((5-(4-(1H-imidazol-1- yl)phenyl)-1H-pyrazol-3- ...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11447469-20220920-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM571620(6-((5-(4-(1H-pyrazol-1- yl)phenyl)-1H-pyrazol-3- y...)
Affinity DataIC50: 1nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11447469-20220920-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM613868(US11739078, Compound A-39 | 5-(1-cyclopentyl-4-(4-...)
Affinity DataIC50: 1.29nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174187(US9102637, 222)
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TNIK (unknown origin) by ADP glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174104(US9102637, 139)
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM613838(US11739078, Compound 103 | US11739078, Compound A-...)
Affinity DataIC50: 1.96nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579739(US11485711, Compound 181 | N-(4-((5-(4-(1H-pyrazol...)
Affinity DataIC50: 2nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM613838(US11739078, Compound 103 | US11739078, Compound A-...)
Affinity DataIC50: 2nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174202(US9102637, 237)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM613765(US11739078, Compound 18 | US11739078, Compound B-1...)
Affinity DataIC50: 2.33nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174160(US9102637, 195)
Affinity DataIC50: 2.5nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174186(US9102637, 221)
Affinity DataIC50: 2.60nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174150(US9102637, 185)
Affinity DataIC50: 2.70nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM613877(US11739078, Compound A-52 | 4-(4-(5-(1-cyclopentyl...)
Affinity DataIC50: 2.80nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174196(US9102637, 231)
Affinity DataIC50: 2.90nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174185(US9102637, 220)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174215(US9102637, 250)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579693(US11485711, Compound 81 | 3-ethyl-4-((5-(4- hydrox...)
Affinity DataKd:  3nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50424547(CHEMBL2312144)
Affinity DataIC50: 3nMAssay Description:Inhibition of TNIK (unknown origin) by ADP glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM579743(US11485711, Compound 187 | N-(4-((5-(4-(1H-pyrazol...)
Affinity DataIC50: 3nMAssay Description:The inhibitory properties of compounds were evaluated with TNIK kinase enzyme system and luminescent ADP-GloFigure US11485711-20221101-P00001 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM174173(US9102637, 208)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50643689(CHEMBL5595897)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human TNIK (1 to 367 residues) using RLGRDKYKTLRQI as substrate incubated for 40 mins in presence of ATP at Km concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
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