Compile Data Set for Download or QSAR
Report error Found 306 Enz. Inhib. hit(s) with Target = 'Thyrotropin-releasing hormone receptor'
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  0.400nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  0.460nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  0.490nMAssay Description:Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173826(1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...)
Affinity DataEC50:  0.5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  0.520nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  0.680nMAssay Description:Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158398(CHEMBL3780633)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50050531(1-[3-(1-methyl-4-imidazolyl)-2-[2-oxo-(5S)-dihydro...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158404(CHEMBL3780373)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158409(CHEMBL3779931)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173826(1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...)
Affinity DataKi:  3nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196446([N tau(1)-Me-His]-TRH | CHEMBL224730)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  4nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataEC50:  4nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109034(CHEMBL3600449)
Affinity DataEC50:  4nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196446([N tau(1)-Me-His]-TRH | CHEMBL224730)
Affinity DataEC50:  5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  5nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109040(CHEMBL3601782)
Affinity DataEC50:  6nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158396(CHEMBL3781773)
Affinity DataEC50:  9nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158401(CHEMBL3780549)
Affinity DataEC50:  9nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMAssay Description:Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158399(CHEMBL3780802)
Affinity DataEC50:  12nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158409(CHEMBL3779931)
Affinity DataEC50:  12nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataEC50:  13nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158401(CHEMBL3780549)
Affinity DataEC50:  15nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
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