Report error Found 488 Enz. Inhib. hit(s) with Target = 'Toll-like receptor 4'
Affinity DataEC50: 0.00500nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0100nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0140nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0150nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0200nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0280nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0600nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0800nMAssay Description:Agonist activity at human TLR4 expressed in HEK293 cells coexpressed with human MD2/CD14 assessed as activation of NFkappaB signaling after 20 to 24 ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0900nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.110nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.130nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.130nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.190nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.240nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of TNFalpha release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.280nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.310nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.370nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.380nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human TLR4 expressed in HEK293 cells coexpressed with human MD2/CD14 assessed as activation of NFkappaB signaling after 20 to 24 ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.430nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.460nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.480nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.490nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.650nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.680nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.760nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.780nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 0.930nMAssay Description:Agonist activity at human TLR4 in human HEK-Blue hTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataEC50: 0.970nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.990nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 1.10nMAssay Description:Binding affinity to recombinant human TLR4 assessed as dissociation constant up to 200 uM by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of TNFalpha release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of IL-6 productionMore data for this Ligand-Target Pair
Affinity DataEC50: 1.32nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 1.39nMAssay Description:In vitro assays were conducted with Compounds 1-9 and the commercially available TLR4 agonist MPL. For measurement of biological activity various cel...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
Affinity DataKd: 1.40nMAssay Description:Binding affinity to recombinant human TLR4 assessed as dissociation constant up to 200 uM by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at TLR4 in human serum assessed as reduction in LPS-induced TNFalpha production after 3 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
