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Report error Found 8675 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK'
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075813(CHEMBL3415598)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM138200(US8871778, 141)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50548361(CHEMBL4744190)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50628078(CHEMBL5425739)
Affinity DataIC50: 0.0460nMAssay Description:Inhibition of full length recombinant human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of GST-tagged full length human SYK (1 to 635 end residues) expressed in baculovirus expression system preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50548350(CHEMBL4780257)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50628077(CHEMBL5435311)
Affinity DataIC50: 0.0670nMAssay Description:Inhibition of full length recombinant human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM301997(US9598405, 1.6 | US9598405, 1.5)
Affinity DataIC50: 0.0710nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302002(US9598405, 2.1)
Affinity DataIC50: 0.0720nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302016(US9598405, 3.1)
Affinity DataIC50: 0.0730nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50546397(CHEMBL4776352)
Affinity DataIC50: 0.0770nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50628081(CHEMBL5410717)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of full length recombinant human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302034(BDBM302035 | US9598405, 4.1)
Affinity DataIC50: 0.0860nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50548354(CHEMBL4753469)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302018(US9598405, 3.3 | US9598405, 3.7)
Affinity DataIC50: 0.0920nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302028(US9598405, 3.13)
Affinity DataIC50: 0.0970nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50546402(CHEMBL4762995)
Affinity DataIC50: 0.0980nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075922(CHEMBL3415606)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144512(US8969568, 65)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM140337(US8912173, 63)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144541(US8969568, 94)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144510(US8969568, 63)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM140322(US8912173, 48)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075744(CHEMBL3415594)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144516(US8969568, 69)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075740(CHEMBL3415589)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144559(US8969568, 112)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144560(US8969568, 113)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144555(US8969568, 108)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144493(US8969568, 45)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM140394(US8912173, 119)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM177763(US9120785, Example 10 | US9120785, Example 11)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM144532(US8969568, 85)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK [342-635](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM311138(example 6.09 on page 559 of WO15017610)
Affinity DataIC50: 0.100nMAssay Description:Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM138211(US8871778, 190)
Affinity DataIC50: 0.100nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM138212(US8871778, 198)
Affinity DataIC50: 0.100nMT: 2°CAssay Description:Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM140393(US8912173, 118)
Affinity DataIC50: 0.100nMpH: 7.5 T: 2°CAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM301993(BDBM301994 | US9598405, 1.1)
Affinity DataIC50: 0.103nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302029(US9598405, 3.14)
Affinity DataIC50: 0.104nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50548358(CHEMBL4753141)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302032(US9598405, 3.17)
Affinity DataIC50: 0.113nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302000(US9598405, 1.8)
Affinity DataIC50: 0.119nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM302030(US9598405, 3.15)
Affinity DataIC50: 0.127nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM189867(US9670196, 2.3 (R or S)-5-hydroxy-5-{5-[3- methyl-...)
Affinity DataIC50: 0.129nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50628075(CHEMBL5434339)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of full length recombinant human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50548362(CHEMBL4784088)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.133nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50548357(CHEMBL4752008)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
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