Compile Data Set for Download or QSAR
Report error Found 157 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Srms'
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human SRMS using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50: 8nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  13nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  13nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  13nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50560327(CHEMBL4749037)
Affinity DataIC50: 14nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 16nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  18nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM267959(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 19nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  21nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM267790(4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human SRMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50558112(CHEMBL4799627)
Affinity DataIC50: 24nMAssay Description:Inhibition of human SRMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50621890(CHEMBL5415503)
Affinity DataKd:  28nMAssay Description:Binding affinity to SRMS (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM267703((R)-4-(8-amino-5-deutero-3-(1-(3-methoxypropanoyl)...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human SRMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 50nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50: 61nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  62nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  62nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  62nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50268010(CHEMBL4098896)
Affinity DataKd:  64nMAssay Description:Binding affinity to partial length human SRMS expressed in HEK293 cells by active-site-dependent competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50269555(CHEMBL4060757)
Affinity DataIC50: 65nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  72nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  72nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  72nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)
Affinity DataIC50: 76nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50269557(CHEMBL4069387)
Affinity DataIC50: 84nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  100nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50269556(CHEMBL4075954)
Affinity DataIC50: 103nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50577406(CHEMBL4862806)
Affinity DataIC50: 114nMAssay Description:Inhibition of human SRMS by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  160nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human wild type SRMS using PolyEY as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2.5 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50355494(CHEMBL1908396)
Affinity DataKd:  400nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  600nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  610nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  740nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  740nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  740nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  820nMAssay Description:Binding affinity to SRMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  820nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50506460(CHEMBL4467948)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human SRMS by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31099(CHEMBL45741 | Flavopiridol | cid_24867231 | 2-(2-c...)
Affinity DataKd:  1.40E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50613392(CHEMBL5270581)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SRMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Srms(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50613393(CHEMBL5288565)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SRMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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