Compile Data Set for Download or QSAR
Report error Found 421 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Yes'
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.300nMAssay Description:Binding constant for YES kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.300nMAssay Description:Binding constant for YES kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.300nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of YES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of yes kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50184767(CHEMBL3824089 | US10294227, Code 506)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human YES using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P] ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human YES using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P] ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM97937(US8481536, 612 | US8481536, 507)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.800nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.800nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.800nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human YesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.890nMAssay Description:Binding affinity to human YES using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM759149(US12365664, Compound 42)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM378887(US10266537, Compound 31)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM759148(US12365664, Compound 41)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM759135(US12365664, Compound 27)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50514527(CHEMBL4452399 | US12365664, Compound 45)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50514532(CHEMBL4442601 | US12365664, Compound 44)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length recombinant YES using poly(Glu,Tyr)4:1 as substrate incubated for 40 mins in presence of [gamma33P-ATP] by radiometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50514531(CHEMBL4538743 | US12365664, Compound 10)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50193874(CHEMBL436137 | US8481536, 322 | 7-(2,6-dimethylphe...)
Affinity DataIC50: 1nMAssay Description:Inhibition of YesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM759136(US12365664, Compound 28)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50514530(CHEMBL4548584 | US12365664, Compound 48)
Affinity DataIC50: 1nMAssay Description:All examples described herein possessed activity in a commercial assay from SelectScreen Kinase Profiling Services in ThermoFisher Scientific company...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50193874(CHEMBL436137 | US8481536, 322 | 7-(2,6-dimethylphe...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM97982(US8481536, 574)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM97907(US8481536, 606 | US8481536, 471)
Affinity DataIC50: 1.24nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 1.28nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human YES using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50: 2nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 2.10nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  2.30nMAssay Description:Binding constant for YES kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.35nMAssay Description:Inhibition of human YES/YES1 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human YES using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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