Compile Data Set for Download or QSAR
Report error Found 419 Enz. Inhib. hit(s) with Target = 'Uracil nucleotide/cysteinyl leukotriene receptor'
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318027(((2R,3S,4R,5R)-5-(6-amino-2-(phenylethynyl)-9H-pur...)
Affinity DataEC50:  0.0360nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318031(cangrelor | CHEMBL1097279)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318026(((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318025(((2R,3S,4R,5R)-5-(6-chloro-4-(methylamino)-1H-imid...)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646601(6-chloro-7- (difluoromethylthio)-N-[5-(2- fluoroet...)
Affinity DataIC50: 7nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646556(6-chloro-N-[5-(3- fluoropropyl)-4,6-dimethoxy- pyr...)
Affinity DataIC50: 7nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646555(6-chloro-N-[5-(2,2- difluoroethyl)-4,6-dimethoxy- ...)
Affinity DataIC50: 8nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646694(6-chloro-N-[5-(2,2- difluoroethyl)-4-methoxy- pyri...)
Affinity DataIC50: 8nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646738(6-bromo-N-[5-(2-cyanoethyl)- 4,6-dimethoxy-pyrimid...)
Affinity DataIC50: 9nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646563(6-chloro-N-[5-(2-cyanoethyl)- 4,6-dimethoxy-pyrimi...)
Affinity DataIC50: 9nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646588(6-bromo-N-[5-(2-cyanoethyl)- 4,6-dimethoxy-pyrimid...)
Affinity DataIC50: 10nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646598(N-[5-(2-cyanoethyl)-4,6- dimethoxy-pyrimidin-2-yl]...)
Affinity DataIC50: 11nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318024(((2R,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-puri...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646548(6-chloro-N-[5-(2- fluoroethoxy)-4,6-dimethoxy- pyr...)
Affinity DataIC50: 11nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646655(6-bromo-N-(4,6-dimethoxy-5- methyl-pyrimidin-2-yl)...)
Affinity DataIC50: 11nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646602(6-chloro-N-[5-(2-cyanoethyl)- 4,6-dimethoxy-pyrimi...)
Affinity DataIC50: 12nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646516(6-chloro-N-[5-(3- fluoropropyl)-4-methoxy- pyrimid...)
Affinity DataIC50: 12nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646557(6-chloro-N-[5-(3,3- difluoropropyl)-4,6- dimethoxy...)
Affinity DataIC50: 12nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646681(6-chloro-N-[5-(2,2- difluoroethyl)-4-methoxy- pyri...)
Affinity DataIC50: 13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646554(6-chloro-N-[5-(2-fluoroethyl)- 4,6-dimethoxy-pyrim...)
Affinity DataIC50: 13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646778(US20240025883, Example 283)
Affinity DataIC50: 13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646551(N-(5-allyl-4,6-dimethoxy- pyrimidin-2-yl)-6-chloro...)
Affinity DataIC50: 13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50239015(CHEBI:6993 | MK-476 | Montelukast Sodium | Singula...)
Affinity DataKd:  13nMAssay Description:Binding affinity to immobilized Halo tag-fused CysLT receptor (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646606(US20240025883, Example 288 | 6-bromo-N-[5-(2,2- di...)
Affinity DataIC50: 13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646713(6-chloro-N-[5-(2-cyanoethyl)- 4,6-dimethoxy-pyrimi...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646747(US20240025883, Example 253 | N-[5-(2-cyanoethyl)-4...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646731(N-[5-(2,2-difluoroethyl)-4,6- dimethoxy-pyrimidin-...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646636(7-bromo-6-chloro-N-[5-(2- fluoroethoxy)-4-methoxy-...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646597(N-[5-(2,2-difluoroethoxy)-4,6- dimethoxy-pyrimidin...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646600(6-chloro-N-[5-(2-cyanoethyl)- 4-methoxy-pyrimidin-...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646760(6-chloro-N-[5- (cyanomethoxy)-4,6- dimethoxy-pyrim...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646564(6-chloro-N-(5-cyclopropyl- 4,6-dimethoxy-pyrimidin...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646702(6-chloro-N-[5-(3,3- difluoropropyl)-4-methoxy- pyr...)
Affinity DataIC50: 14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646667(US20240025883, Example 172)
Affinity DataIC50: 15nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646729(6-chloro-N-[5-(2,2- difluoroethyl)-4-methoxy- pyri...)
Affinity DataIC50: 16nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646616(6-chloro-N-[5-(3,3- difluoropropyl)-4,6- dimethoxy...)
Affinity DataIC50: 16nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646691(6-bromo-N-[5-(2,2- difluoroethyl)-4-methoxy- pyrim...)
Affinity DataIC50: 16nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646739(6-bromo-N-[5- (cyanomethoxy)-4,6- dimethoxy-pyrimi...)
Affinity DataIC50: 16nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646607(6-bromo-N-[5-(3,3- difluoropropyl)-4,6- dimethoxy-...)
Affinity DataIC50: 16nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646553(6-chloro-N-(4,6-dimethoxy-5- propyl-pyrimidin-2-yl...)
Affinity DataIC50: 17nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646549(6-chloro-N-[5-(2,2- difluoroethoxy)-4,6- dimethoxy...)
Affinity DataIC50: 17nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646550(6-chloro-N-[4,6-dimethoxy-5- (1,1,2- trifluoroetho...)
Affinity DataIC50: 17nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646712(6-chloro-N-[5-(2,2- difluoroethyl)-4,6-dimethoxy- ...)
Affinity DataIC50: 17nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50603973(CHEMBL5172549)
Affinity DataKd:  17nMAssay Description:Binding affinity to immobilized Halo tag-fused CysLT receptor (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646682(6-chloro-N-[5-(3,3- difluoropropyl)-4-methoxy- pyr...)
Affinity DataIC50: 18nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646714(6-chloro-N-[5- (cyanomethoxy)-4,6- dimethoxy-pyrim...)
Affinity DataIC50: 18nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646587(6-bromo-N-[5-(2,2- difluoroethoxy)-4,6- dimethoxy-...)
Affinity DataIC50: 18nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646705(6,7-dichloro-N-[5-(2,2- difluoroethyl)-4-methoxy- ...)
Affinity DataIC50: 18nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646741(6-bromo-N-[5- (cyanomethoxy)-4,6- dimethoxy-pyrimi...)
Affinity DataIC50: 19nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM646561(6-chloro-N-[4,6-dimethoxy-5- (2-methoxyethyl)pyrim...)
Affinity DataIC50: 19nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

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