Recently Added Targets
- Enoyl-[acyl-carrier-protein] reductase [NADH], Acinetobacter baumannii, A0A6F8TJQ1 (Curated 11/08/24), fabI: 4 subμM ligands
- Trehalose monomycolate exporter MmpL3, Mycobacterium smegmatis, A0QP27 (Curated 12/14/24), mmpL3: 2 subμM ligands
- Macrophage-expressed gene 1 protein, Mouse, A1L314 (Curated 12/18/24), Mpeg1: 2 subμM ligands
- Albumin, Crab-eating macaque, A2V9Z4 (Curated 12/17/24), ALB: 1 subμM ligands
- UDP-2,3-diacylglucosamine hydrolase, Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578), A6T5R0 (Curated 11/26/24), lpxH: 24 subμM ligands
- DNA gyrase subunit B, Escherichia coli, C3SLN3 (Curated 12/13/24), gyrB: 45 subμM ligands
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, Human, O00469 (Curated 12/19/24), PLOD2: 3 subμM ligands
- Serine/threonine-protein phosphatase with EF-hands 1, Human, O14829 (Curated 12/14/24), PPEF1: 1 subμM ligands
- Transcription factor MafG, Human, O15525 (Curated 12/16/24), MAFG: 1 subμM ligands
- 4'-phosphopantetheinyl transferase PptT, Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), O33336 (Curated 12/18/24), pptT: 4 subμM ligands
- Neuropilin-2, Human, O60462 (Curated 12/19/24), NRP2: 1 subμM ligands
- Diacylglycerol kinase iota, Human, O75912 (Curated 12/18/24), DGKI: 2 subμM ligands
- Cdk-related protein kinase 6, malaria parasite P. falciparum, O77239 (Curated 12/17/24), PK6: 67 subμM ligands
- Collagen alpha-1(I) chain, Human, P02452 (Curated 12/22/24), COL1A1: 7 subμM ligands
- Latent membrane protein 1, HHV-4, P03230 (Curated 12/14/24), LMP1: 1 subμM ligands
- Vimentin, Human, P08670 (Curated 12/18/24), VIM: 1 subμM ligands
- Small ribosomal subunit protein uS2, Human, P08865 (Curated 12/14/24), RPSA: 1 subμM ligands
- CD99 antigen, Human, P14209 (Curated 12/17/24), CD99: 2 subμM ligands
- Ras-related C3 botulinum toxin substrate 2, Human, P15153 (Curated 12/14/24), RAC2: 1 subμM ligands
- Galectin-1, Mouse, P16045 (Curated 12/18/24), Lgals1: 1 subμM ligands
- Heat shock 70 kDa protein 6, Human, P17066 (Curated 12/14/24), HSPA6: 1 subμM ligands
- Probable ATP-dependent RNA helicase DDX5, Human, P17844 (Curated 12/21/24), DDX5: 1 subμM ligands
- Tumor necrosis factor receptor superfamily member 1B, Human, P20333 (Curated 12/17/24), TNFRSF1B: 1 subμM ligands
- Oxysterol-binding protein 1, Human, P22059 (Curated 12/20/24), OSBP: 32 subμM ligands
- NKG2-D type II integral membrane protein, Human, P26718 (Curated 12/22/24), KLRK1: 11 subμM ligands
- Metalloproteinase inhibitor 3, Human, P35625 (Curated 12/14/24), TIMP3: 8 subμM ligands
- Serine/threonine-protein phosphatase 4 catalytic subunit, Human, P60510 (Curated 12/14/24), PPP4C: 1 subμM ligands
- Ras-related C3 botulinum toxin substrate 3, Human, P60763 (Curated 12/14/24), RAC3: 2 subμM ligands
- Mitogen-activated protein kinase kinase kinase kinase 1, Mouse, P70218 (Curated 12/14/24), Map4k1: 1 subμM ligands
- S-adenosylmethionine synthase isoform type-1, Human, Q00266 (Curated 12/19/24), MAT1A: 1 subμM ligands
- Xanthine dehydrogenase/oxidase, Mouse, Q00519 (Curated 12/18/24), Xdh: 1 subμM ligands
- Inactive tyrosine-protein kinase transmembrane receptor ROR1, Human, Q01973 (Curated 12/18/24), ROR1: 15 subμM ligands
- Tyrosine-protein kinase transmembrane receptor ROR2, Human, Q01974 (Curated 12/18/24), ROR2: 4 subμM ligands
- Matrilysin, Mouse, Q10738 (Curated 12/20/24), Mmp7: 1 subμM ligands
- Interleukin enhancer-binding factor 3, Human, Q12906 (Curated 12/21/24), ILF3: 2 subμM ligands
- Mannosyl-oligosaccharide glucosidase, Human, Q13724 (Curated 11/25/24), MOGS: 190 subμM ligands
- Cyclin-dependent kinase 12, Mouse, Q14AX6 (Curated 12/18/24), Cdk12: 2 subμM ligands
- MHC class I polypeptide-related sequence A, Human, Q29983 (Curated 12/22/24), MICA: 20 subμM ligands
- Sigma intracellular receptor 2, Bovine, Q3MHW7 (Curated 12/14/24), TMEM97: 2 subμM ligands
- Lysophospholipase-like protein 1, Mouse, Q3UFF7 (Curated 12/21/24), Lyplal1: 1 subμM ligands
- Beta-lactamase, Escherichia coli, Q4GY26 (Curated 12/15/24), blaTEM-1: 2 subμM ligands
- Retinal dehydrogenase 2, Mouse, Q62148 (Curated 11/21/24), Aldh1a2: 21 subμM ligands
- Protein arginine N-methyltransferase 9, Human, Q6P2P2 (Curated 12/19/24), PRMT9: 2 subμM ligands
- GDNF family receptor alpha-like, Human, Q6UXV0 (Curated 12/19/24), GFRAL: 2 subμM ligands
- ATP-dependent RNA helicase DHX33, Mouse, Q80VY9 (Curated 12/22/24), Dhx33: 2 subμM ligands
- Beta-lactamase, Escherichia coli, Q840M4 (Curated 12/15/24), blaCTX-M-27: 1 subμM ligands
- threonine--tRNA ligase, Plasmodium falciparum (isolate 3D7), Q8IIA4 (Curated 12/18/24), : 7 subμM ligands
- N-acetylaspartylglutamate synthase A, Human, Q8IXN7 (Curated 12/06/24), RIMKLA: 3 subμM ligands
- Bifunctional peptidase and arginyl-hydroxylase JMJD5, Human, Q8N371 (Curated 12/19/24), KDM8: 10 subμM ligands
- ADP-ribosylation factor GTPase-activating protein 1, Human, Q8N6T3 (Curated 12/14/24), ARFGAP1: 1 subμM ligands
- Interleukin-17 receptor E, Human, Q8NFR9 (Curated 12/18/24), IL17RE: 40 subμM ligands
- 17-beta-hydroxysteroid dehydrogenase 13, Mouse, Q8VCR2 (Curated 12/22/24), Hsd17b13: 15 subμM ligands
- Ryanodine receptor 2, Human, Q92736 (Curated 12/21/24), RYR2: 3 subμM ligands
- Crossover junction endonuclease MUS81, Human, Q96NY9 (Curated 12/14/24), MUS81: 2 subμM ligands
- Myosin-1, Bovine, Q9BE40 (Curated 11/25/24), MYH1: 112 subμM ligands
- Solute carrier family 26 member 6, Human, Q9BXS9 (Curated 12/14/24), SLC26A6: 1 subμM ligands
- Melanoma-associated antigen E1, Human, Q9HCI5 (Curated 11/07/24), MAGEE1: 8 subμM ligands
- Beta-lactamase, Escherichia coli, Q9L5C7 (Curated 12/15/24), blaCTX-M-14: 3 subμM ligands
- Dual oxidase 1, Human, Q9NRD9 (Curated 12/19/24), DUOX1: 1 subμM ligands
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, Human, Q9NY97 (Curated 12/17/24), B3GNT2: 36 subμM ligands
- Insulin-like growth factor 2 mRNA-binding protein 1, Human, Q9NZI8 (Curated 12/19/24), IGF2BP1: 2 subμM ligands
- Zinc finger protein Aiolos, Human, Q9UKT9 (Curated 12/21/24), IKZF3: 11 subμM ligands
- DDB1- and CUL4-associated factor 1, Human, Q9Y4B6 (Curated 12/22/24), DCAF1: 6 subμM ligands
- HIV-1 protease, Human immunodeficiency virus, Q9YQ30 (Curated 12/19/24), HIV-1 protease: 1 subμM ligands
BindingDB Archive
BindingDB is archived quarterly at UC San Diego Library Digital Collections.
Coronavirus Binding Data
BindingDB has accelerated collection of COVID related data. You can find the result here.
Try the BindingDB Browser Extension
We are excited to share our new browser extension, BDBFind. Once installed in your browser, BDBFind automatically lets you know when BindingDB has the data from an article, PubMed Entry, or US Patent you are looking at online and provides direct links to view or download the data. Get BDBFind by searching for it in the Chrome webstore or in Firefox extensions or by following these links:
- https://chrome.google.com/webstore/search/bdbfind (Once installed, click on the "jigsaw puzzle" icon to keep the BDB icon displayed.)
- https://addons.mozilla.org/addon/bdbfind.
Watch BDBFind in action in this 1.5 minute video: To send feedback about BDBfind, please email us at bindingdb@gmail.com.
BindingDB Data Curation
BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of December 31, 2024, BindingDB's patent dataset comprises:
- Patents: 7,534
- Binding measurements: 1,161,587
- Compounds: 571,885
- Target proteins: 2,792
- Assays: 10,739
- Average Number of Targets per Patent: 1.90
BindingDB curates a set of journals not covered by other public databases. As of December 31, 2024, the status of this curation effort is as follows:
- ACS Chemical Biology 2006-2017 (vol 1-12) data
- ACS BioChemistry 1965-2017 (vol 4-56) data
- Bioorganic Chemistry 1990-2017 (vol 18-73) data
- BMC Chemical Biology 2001-2010 (vol 1-10) data
- ChemBioChem 2001-2017 (vol 2-18) data
- Chemical Biology & Drug Design 2006-2017 (vol 67-89) data
- Chemistry & Biology 1995-2015 (vol 2-22) data
- Journal of Biological Chemistry 1982-2014 (vol 257-289) data
- Journal of Chemical Biology 2010-2010 (vol 3-3) data
- Journal of Enzyme Inhibition and Medicinal Chemistry 2002-2014 (vol 17-29) data
- Nature Chemical Biology 2005-2017 (vol 1-13) data
- Medicinal Chemistry Research 2004-2014 (vol 13-23) data
BindingDB is supported by NIH's National Institute of General Medical Sciences (R24GM144232), and is located at the Skaggs School of Pharmacy and Pharmaceutical Sciences of the University of California San Diego