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Found 98 with Last Name = 'rady' and Initial = 'b'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193240(US9193736, 164)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193125(US9193736, 41)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193112(US9193736, 28)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193120(US9193736, 36)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193245(US9193736, 169)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193096(US9193736, 12)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193244(US9193736, 168)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193186(US9193736, 102)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193184(US9193736, 100)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193138(US9193736, 54)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193149(US9193736, 65)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50536670(CHEMBL4516577)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193097(US9193736, 13)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193090(US9193736, 6)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193252(US9193736, 177)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50536669(CHEMBL4530555)
Affinity DataIC50:  123nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human PDEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human PDE5AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human PDE1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human PDE3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of recombinant CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE9AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Rattus norvegicus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521263(CHEMBL4541658)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521264(CHEMBL4459220)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521265(CHEMBL4464769)
Affinity DataEC50:  89nMAssay Description:Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521266(CHEMBL4463571)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521267(CHEMBL4513748)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521263(CHEMBL4541658)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521269(CHEMBL4591657)
Affinity DataEC50:  4.10nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521266(CHEMBL4463571)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521270(CHEMBL4443853)
Affinity DataEC50:  163nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521271(CHEMBL4534836)
Affinity DataEC50:  28nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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