TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to a thrombin receptor (PAR-1) membrane preparation.More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using testosterone as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using midazolam as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
Affinity DataIC50: 205nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:In vitro antagonist activity against Thrombin induced gel-filtered platelet (GFP) aggregation at 0.15 nM.More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:In vitro antagonist activity against Thrombin induced gel-filtered platelet (GFP) aggregation at 0.15 nM.More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair