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Found 260 with Last Name = 'oksenberg' and Initial = 'd'
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50070679((S)-2-[(S)-2-{(S)-3-(4-Fluoro-phenyl)-2-[(E)-(3-ph...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of [3H]S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to a thrombin receptor (PAR-1) membrane preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using testosterone as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  18nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using midazolam as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129484(CHEMBL308050 | N-(2-Amino-ethyl)-2-[(S)-2-{3-[1-(2...)
Affinity DataIC50:  25nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129486((S)-N-[1-((S)-2-Amino-ethylcarbamoyl)-2-thiophen-2...)
Affinity DataIC50:  35nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  35nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129487((S)-N-[1-((R)-2-Amino-ethylcarbamoyl)-2-methylsulf...)
Affinity DataIC50:  60nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103034((S)-2-((S)-3-(4-Cyano-phenyl)-2-{3-[1-(2,6-dichlor...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129488((S)-N-[1-((S)-2-Amino-ethylcarbamoyl)-2-pyridin-4-...)
Affinity DataIC50:  70nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129478(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  70nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129495(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  90nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103015((S)-5-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103029((S)-6-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103015((S)-5-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129493(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  120nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103014((S)-2-[(S)-2-{3-[1-(4-Fluoro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129491((S)-N-[1-((S)-3-Amino-propylcarbamoyl)-2-(1H-imida...)
Affinity DataIC50:  130nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103038((S)-2-[(S)-2-{3-[1-(2-Chloro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103025((S)-5-Guanidino-2-[(S)-2-{3-[1-(2-methyl-benzyl)-3...)
Affinity DataIC50:  150nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103016(4-Amino-N-benzyl-2-[(S)-2-{3-[1-(2,6-dichloro-benz...)
Affinity DataIC50:  160nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129489(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  160nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103016(4-Amino-N-benzyl-2-[(S)-2-{3-[1-(2,6-dichloro-benz...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103024((S)-5-Guanidino-2-((S)-3-(4-methoxy-phenyl)-2-{3-[...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103017((S)-N-[1-Benzylcarbamoyl-2-(3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090677(4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfon...)
Affinity DataIC50:  205nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103020((S)-2-[(S)-2-{3-[3-Diethylaminomethyl-1-(3-methyl-...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129490(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  230nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103018((S)-2-[(S)-2-{3-[3-Diethylaminomethyl-1-(2-methyl-...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103036(2-[(S)-2-{3-[1-(2,6-Dichloro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  240nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103036(2-[(S)-2-{3-[1-(2,6-Dichloro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  240nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098218((S)-2-[(S)-2-{3-[1-(4-Fluoro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103036(2-[(S)-2-{3-[1-(2,6-Dichloro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129480(5-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  310nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103026((S)-5-Guanidino-2-((S)-3-(4-methoxy-phenyl)-2-{3-[...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129485(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  330nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098216(2-Amino-4-({benzylcarbamoyl-[2-{3-[1-(2,6-dichloro...)
Affinity DataIC50:  340nMAssay Description:In vitro antagonist activity against Thrombin induced gel-filtered platelet (GFP) aggregation at 0.15 nM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103016(4-Amino-N-benzyl-2-[(S)-2-{3-[1-(2,6-dichloro-benz...)
Affinity DataIC50:  340nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  370nMAssay Description:In vitro antagonist activity against Thrombin induced gel-filtered platelet (GFP) aggregation at 0.15 nM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103038((S)-2-[(S)-2-{3-[1-(2-Chloro-benzyl)-3-pyrrolidin-...)
Affinity DataIC50:  380nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103037((S)-2-[(S)-2-{3-[3-Azetidin-1-ylmethyl-1-(4-fluoro...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103028(CHEMBL305188 | N-Benzyl-2-[(S)-2-{3-[1-(2,6-dichlo...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103028(CHEMBL305188 | N-Benzyl-2-[(S)-2-{3-[1-(2,6-dichlo...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129492(4-Amino-N-(3-amino-propyl)-2-((S)-3-(4-chloro-phen...)
Affinity DataIC50:  430nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129481(4-Amino-N-benzyl-2-[(S)-2-{3-[1-(2,6-dichloro-benz...)
Affinity DataIC50:  440nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103017((S)-N-[1-Benzylcarbamoyl-2-(3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  460nMAssay Description:In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103017((S)-N-[1-Benzylcarbamoyl-2-(3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  460nMAssay Description:In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129482(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  480nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103021((S)-N-(2-Amino-1-benzylcarbamoyl-ethyl)-2-{3-[1-(2...)
Affinity DataIC50:  500nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50129479(4-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3-pyr...)
Affinity DataIC50:  500nMAssay Description:Ability to inhibit the binding of [3H]-S-(p-F-Phe)-homoarginine-L-homoarginine-KY-NH2 to thrombin receptor on the membranes of CHRF-288-11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103015((S)-5-Amino-2-[(S)-2-{3-[1-(2,6-dichloro-benzyl)-3...)
Affinity DataIC50:  500nMAssay Description:In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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