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Found 102 with Last Name = 'nason' and Initial = 'dm'
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032162(3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-5,7-dihydro-...)
Affinity DataIC50:  0.330nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032161(3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-7-methyl-5,7...)
Affinity DataIC50:  0.480nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032164(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dihydroiso...)
Affinity DataIC50:  0.570nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032163(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5H-isoxazolo[5...)
Affinity DataIC50:  0.950nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255776(CHEMBL4075310)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032165(CHEMBL92736 | CHEMBL94217 | N-{3-[2-(1-Benzyl-pipe...)
Affinity DataIC50:  2.80nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255775(CHEMBL4079080)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032160(3-(2-(1-benzylpiperidin-4-yl)ethyl)-6H-isoxazolo[5...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM60622(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255806(CHEMBL4097100)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255777(CHEMBL4061795)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255777(CHEMBL4061795)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255805(CHEMBL4086931)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255786(CHEMBL4076777)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150885(6-(4-Dimethylaminomethyl-5-ethyl-2-methoxy-phenyl)...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150887(6-[4-(2-Dimethylamino-ethoxy)-5-ethyl-2-methoxy-ph...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  73nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150884(6-[4-(3-Dimethylamino-propyl)-5-ethyl-2-methoxy-ph...)
Affinity DataIC50:  75nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150890(6-[4-(2-Dimethylamino-ethyl)-5-ethyl-2-methoxy-phe...)
Affinity DataIC50:  75nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150883(6-[4-(2-Dimethylamino-ethoxy)-2,5-dimethoxy-phenyl...)
Affinity DataIC50:  112nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255814(CHEMBL4059563)
Affinity DataIC50:  132nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081082(2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150888(6-[4-(3-Dimethylamino-propyl)-2,5-dimethoxy-phenyl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150886(6-[4-(2-Dimethylamino-ethyl)-2,5-dimethoxy-phenyl]...)
Affinity DataIC50:  235nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255813(CHEMBL4092367)
Affinity DataIC50:  242nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255808(CHEMBL4068209)
Affinity DataIC50:  354nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255787(CHEMBL4104811)
Affinity DataIC50:  445nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255810(CHEMBL4081518)
Affinity DataIC50:  582nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150889(6-(4-Dimethylaminomethyl-2,5-dimethoxy-phenyl)-pyr...)
Affinity DataIC50:  810nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50081082(2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...)
Affinity DataIC50:  887nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255807(CHEMBL4089392)
Affinity DataIC50:  890nMAssay Description:Inhibition of recombinant human MAGL using fluorogenic-7HCA as substrate preincubated for 30 mins followed by substrate addition measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255787(CHEMBL4104811)
Affinity DataIC50:  970nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255805(CHEMBL4086931)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255808(CHEMBL4068209)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032160(3-(2-(1-benzylpiperidin-4-yl)ethyl)-6H-isoxazolo[5...)
Affinity DataIC50:  2.20E+3nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240693(CHEMBL4097569)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255775(CHEMBL4079080)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255786(CHEMBL4076777)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150887(6-[4-(2-Dimethylamino-ethoxy)-5-ethyl-2-methoxy-ph...)
Affinity DataIC50:  3.71E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032163(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5H-isoxazolo[5...)
Affinity DataIC50:  3.90E+3nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032164(3-(2-(1-benzylpiperidin-4-yl)ethyl)-5,6-dihydroiso...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255776(CHEMBL4075310)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032161(3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-7-methyl-5,7...)
Affinity DataIC50:  4.50E+3nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240693(CHEMBL4097569)
Affinity DataIC50:  4.94E+3nMAssay Description:Inhibition of PDE11A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032162(3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-5,7-dihydro-...)
Affinity DataIC50:  7.20E+3nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150884(6-[4-(3-Dimethylamino-propyl)-5-ethyl-2-methoxy-ph...)
Affinity DataIC50: >7.70E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50150885(6-(4-Dimethylaminomethyl-5-ethyl-2-methoxy-phenyl)...)
Affinity DataIC50:  8.83E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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