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Found 285 with Last Name = 'gonzález' and Initial = 'g'
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379268(CHEMBL3216556)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343610((+)-methyl(1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKi:  3.95nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343612((+)-Methyl(1R,2S)-2-[(4-Hydroxy-4-phenylpiperidin-...)
Affinity DataKi:  5.02nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50335605((+/-)-4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-y...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343611((-)-(1S,2R)-methyl 2-((4-(4-chlorophenyl)-4-hydrox...)
Affinity DataKi:  5.61nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343613((-)-Methyl(1S,2R)-2-[(4-Hydroxy-4-phenylpiperidin-...)
Affinity DataKi:  7.01nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343614((+)-Methyl(1R,2S)-2-{[(3-endo)-3-(4-Chlorophenyl)-...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Affinity DataKi:  69.4nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343617((-)-Methyl(1S,2R)-2-{[(1R,5S/1S,5R)-3-(4-Chlorophe...)
Affinity DataKi:  198nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343616((+)-Methyl(1R,2S)-2-{[(1R,5S/1S,5R)-3-(4-Chlorophe...)
Affinity DataKi:  397nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50343615((-)-Methyl(1S,2R)-2-{[(3-endo)-3-(4-Chlorophenyl)-...)
Affinity DataKi:  520nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10590(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10586(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379273(CHEMBL1994202 | US9238626, (-)-Huprine Y HCl)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50200340((+/-)-huprine Y-HCl | (+/-)-huprineY hydrochloride...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10587(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(6-...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10583(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(1,...)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50322768(5-Chloro-7-{[9-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10589(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(6-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10585(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(1,...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10584(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{7-[(1,...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of cyclooxygenase-1 via inhibition of TXB2 generation in the presence of 1 uM arachidonic acid in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  2nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50027470(CHEMBL3216778)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10588(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{7-[(6-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50027471(CHEMBL3216554)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322768(5-Chloro-7-{[9-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322777(2-Methyl-7-{[10-(1,2,3,4-tetrahydroacridin-9-ylami...)
Affinity DataIC50:  7nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BuChE in horse serum using butyrylthiocholine as substrate by Ellman methodMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of equine serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BuChE in horse serum by Ellman methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM8987(6-chloro-1,2,3,4-tetrahydroacridin-9-amine | 6-chl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379274(CHEMBL2011499 | US9238626, (+)-Huprine Y HCl)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  20nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM10583(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(1,...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322770(7-{[7-(1,2,3,4-Tetrahydroacridin-9-ylamino)heptyla...)
Affinity DataIC50:  25nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratorios Menarini

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of PGE-2 generation by LPS-stimulated monocytes isolated from human blood.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50027471(CHEMBL3216554)
Affinity DataIC50:  27nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50027470(CHEMBL3216778)
Affinity DataIC50:  27nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322782(5-Chloro-7-{{3-{methyl[3-(1,2,3,4-tetrahydroacridi...)
Affinity DataIC50:  30nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322771(7-{[8-(1,2,3,4-Tetrahydroacridin-9-ylamino)octylam...)
Affinity DataIC50:  30nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM10589(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(6-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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