Found 204 with Last Name = 'smaldone' and Initial = 'g' TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataKi: 110nMAssay Description:Noncompetitive inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataKi: 390nMAssay Description:Competitive inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Mixed-type inhibition of B6CBAF1/J mouse brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+3nMAssay Description:Mixed-type inhibition of B6CBAF1/J mouse brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno
Curated by ChEMBL
University of Salerno
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno
Curated by ChEMBL
University of Salerno
Curated by ChEMBL
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno
Curated by ChEMBL
University of Salerno
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno
Curated by ChEMBL
University of Salerno
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno
Curated by ChEMBL
University of Salerno
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate preincubated for 10 mins at pH 8More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno
Curated by ChEMBL
University of Salerno
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate preincubated for 10 mins at pH 6More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 135nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 331nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 570nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 589nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of FAAH (unknown origin) expressed in human HeLa cells transfected with empty vector using [3H]AEA as substrate after 2 hrs by liquid scin...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of FAAH (unknown origin) expressed in human HeLa cells using [3H]AEA as substrate after 2 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University of Cagliari
Curated by ChEMBL
University of Cagliari
Curated by ChEMBL
Affinity DataIC50: 740nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
