TargetD(1B) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataKi: 5.5nMAssay Description:Competitive binding affinity to human D5R in transfected cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataKi: 5.5nMAssay Description:Competitive binding affinity to human D2R in transfected cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Competitive binding affinity to human D3R in transfected cellsMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataKi: 5.5nMAssay Description:Competitive binding affinity to human D4R in transfected cellsMore data for this Ligand-Target Pair
Affinity DataKi: 50.1nMAssay Description:Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 7.94E+4nMAssay Description:Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
Hospital Regional Universitario
Curated by ChEMBL
Hospital Regional Universitario
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion at 0.1 nM i...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 1.31E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 2.17E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Hospital Regional Universitario
Curated by ChEMBL
Hospital Regional Universitario
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Positive allosteric modulator activity at human GLP-1R expressed in HEK293 cells assessed as activation of calcium fluxMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 1.59E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
Affinity DataKd: 1.56E+5nMAssay Description:Binding affinity to human serum albumin at 5 uM incubated for 12 mins by HPLC-MS analysisMore data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
Hospital Regional Universitario
Curated by ChEMBL
Hospital Regional Universitario
Curated by ChEMBL
Affinity DataEC50: 0.25nMAssay Description:Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion incubated f...More data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
Hospital Regional Universitario
Curated by ChEMBL
Hospital Regional Universitario
Curated by ChEMBL
Affinity DataEC50: 0.00800nMAssay Description:Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion incubated f...More data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Hospital Regional Universitario
Curated by ChEMBL
Hospital Regional Universitario
Curated by ChEMBL
Affinity DataEC50: 0.100nMAssay Description:Positive allosteric modulator activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of GLP-1(7-36)NH2 induced cAMP accumulation...More data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Hospital Regional Universitario
Curated by ChEMBL
Hospital Regional Universitario
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Positive allosteric modulator activity at human GLP-1R expressed in HEK293 cells assessed as activation of calcium fluxMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 1.26E+3nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 4.93E+3nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 2.18E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 1.85E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 1.08E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 2.30E+3nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 1.27E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Positive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosph...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 3.02E+4nMAssay Description:Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound ...More data for this Ligand-Target Pair