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Found 98 with Last Name = 'mosyak' and Initial = 'l'
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35221(pyrimidoindolone, 25b)
Affinity DataIC50:  1.29nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35223(pyrimidoindolone, 25d)
Affinity DataIC50:  2.32nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35202(pyrimidoindolone, 11k)
Affinity DataIC50:  2.40nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157485(4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl...)
Affinity DataIC50:  3nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35220(pyrimidoindolone, 25a)
Affinity DataIC50:  3.30nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35203(pyrimidoindolone, 11l)
Affinity DataIC50:  4.43nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35206(pyrimidoindolone, 14a)
Affinity DataIC50:  4.99nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  5nMAssay Description:Inhibition of src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  5nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  5nMAssay Description:Inhibition of Abl 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM19730(3,3-dimethyl-8-{[(2S)-2-(phenoxymethyl)pyrrolidine...)
Affinity DataIC50:  7nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35204(pyrimidoindolone, 11m)
Affinity DataIC50:  7.18nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35199(pyrimidoindolone, 11h)
Affinity DataIC50:  7.81nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35205(pyrimidoindolone, 11n)
Affinity DataIC50:  10.1nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35200(pyrimidoindolone, 11i)
Affinity DataIC50:  10.2nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35192(pyrimidoindolone, 11a)
Affinity DataIC50:  10.8nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35201(pyrimidoindolone, 11j)
Affinity DataIC50:  12.6nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35224(pyrimidoindolone, 25e)
Affinity DataIC50:  13.6nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35193(pyrimidoindolone, 11b)
Affinity DataIC50:  13.8nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35207(pyrimidoindolone, 14b)
Affinity DataIC50:  14.3nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35222(pyrimidoindolone, 25c)
Affinity DataIC50:  14.8nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157496(4-[1-(2,5-dichlorophenyl)-6-hydroxy-1H-indazol-3-y...)
Affinity DataIC50:  15nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  16nMAssay Description:Inhibition of HckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157488(4-(7-chloro-1-cyclopentyl-1H-indazol-3-yl)phenol |...)
Affinity DataIC50:  18nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157483(4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol |...)
Affinity DataIC50:  18nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157501(4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl...)
Affinity DataIC50:  20nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35197(pyrimidoindolone, 11f)
Affinity DataIC50:  23nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  24nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35225(pyrimidoindolone, 25f)
Affinity DataIC50:  24.6nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157498(4-(1-butyl-7-chloro-1H-indazol-3-yl)phenol | CHEMB...)
Affinity DataIC50:  25nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35195(pyrimidoindolone, 11d)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157491(4-[1-(2,5-difluorophenyl)-6-hydroxy-1H-indazol-3-y...)
Affinity DataIC50:  31nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  35nMAssay Description:Inhibition of LCK by LANCE FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35194(pyrimidoindolone, 11c)
Affinity DataIC50:  37nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157504(4-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenol | ...)
Affinity DataIC50:  37nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50:  38nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157489(4-[1-(3-fluorophenyl)-6-hydroxy-1H-indazol-3-yl]be...)
Affinity DataIC50:  39nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157503(4-(7-methyl-1-propyl-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  40nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157500(4-[6-hydroxy-1-(4-methylphenyl)-1H-indazol-3-yl]be...)
Affinity DataIC50:  40nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35208(pyrimidoindolone, 14c)
Affinity DataIC50:  43.6nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157486(4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL | CH...)
Affinity DataIC50:  48nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157508(4-[1-(3-chlorophenyl)-6-hydroxy-1H-indazol-3-yl]be...)
Affinity DataIC50:  50nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157502(4-(7-chloro-1-propyl-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  52nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35209(pyrimidoindolone, 14d)
Affinity DataIC50:  59nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157507(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]-3-...)
Affinity DataIC50:  59nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157487(4-(6-hydroxy-1-propyl-1H-indazol-3-yl)benzene-1,3-...)
Affinity DataIC50:  62nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35196(pyrimidoindolone, 11e)
Affinity DataIC50:  81nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35198(pyrimidoindolone, 11g)
Affinity DataIC50:  82nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157493(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]ben...)
Affinity DataIC50:  93nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
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