TargetWD repeat-containing protein 5(Homo sapiens (Human))
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Affinity DataKi: 0.0440nMAssay Description:Competitive inhibition of human N-terminal His6-SUMO tagged WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold(DE3) cells using 10-mer...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Binding affinity to human MCH-R1 expressed in CHO/Galpha16 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.20E+3nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.50E+3nMAssay Description:Inhibition constant obtained from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.50E+3nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.50E+3nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.80E+4nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.30E+4nMAssay Description:Inhibition constant from beta adrenergic receptor binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Plasma renin inhibitory activity was evaluated in lyophilized human plasma with 0.1%EDTAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMT: 2°CAssay Description:Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Plasma renin inhibitory activity was evaluated in lyophilized human plasma with 0.1%EDTAMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.8Assay Description:50 μl of substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, was placed in black microtitre plate...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.8Assay Description:50 μl of substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, was placed in black microtitre plate...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.8Assay Description:50 μl of substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, was placed in black microtitre plate...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.8Assay Description:50 μl of substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, was placed in black microtitre plate...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.8Assay Description:50 μl of substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, was placed in black microtitre plate...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.8Assay Description:50 μl of substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, was placed in black microtitre plate...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [125I-MCH] from human MCH receptor 1 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [125I-MCH] from human MCH receptor 1 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human DPP4 in Caco2 cells by fluorescene assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Displacement of [125I-MCH] from human MCH receptor 1 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Displacement of [125I-MCH] from human MCH receptor 1 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of DPP4 in human Caco-2 cells after 1 hrMore data for this Ligand-Target Pair