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Found 505 with Last Name = 'connolly' and Initial = 'm'
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052513(8-Methyl-3-(2-oxo-propyl)-1-phenethyl-1,3,8-triaza...)
Affinity DataKi:  0.150nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474799(CHEMBL416690)
Affinity DataKi:  0.400nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052512(1-Cyclohexyl-8-methyl-3-(2-oxo-propyl)-1,3,8-triaz...)
Affinity DataKi:  0.570nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124914(CHEMBL161180 | N-(3,5-Dichloro-benzyl)-4-trifluoro...)
Affinity DataKi:  0.600nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474791(CHEMBL65693)
Affinity DataKi:  0.680nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124885((E)-N-(2-Methoxy-benzyl)-3-phenyl-acrylamidine | C...)
Affinity DataKi:  0.700nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474809(CHEMBL65454)
Affinity DataKi:  0.820nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474789(CHEMBL68134)
Affinity DataKi:  0.850nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...)
Affinity DataKi:  0.990nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068597(1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-piper...)
Affinity DataKi:  1nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124909(CHEMBL159744 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)
Affinity DataKi:  1.20nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212688(2-(3,5-dimethyl-benzyl)-5-trifluoromethoxy-2,3-dih...)
Affinity DataKi:  2nMAssay Description:Binding affinity to NMDA NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068564(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  2nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212685(2-benzofuran-7-ylmethyl-5-trifluoromethoxy-2,3-dih...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to NMDA NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071342(4-Chloro-N-[4-(1H-imidazol-4-yl)-butyl]-N-(4-imida...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474808(CHEMBL65314)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068573(1-(2-Oxo-2-phenyl-acetyl)-piperidine-2-carboxylic ...)
Affinity DataKi:  3nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474792(CHEMBL63200)
Affinity DataKi:  3.20nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212684(2-(2-methoxy-benzyl)-5-trifluoromethoxy-2,3-dihydr...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to NMDA NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124923(CHEMBL162080 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)
Affinity DataKi:  3.90nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071343(4-Chloro-N-[4-(1H-imidazol-4-yl)-butyl]-N-methyl-b...)
Affinity DataKi:  4nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474790(CHEMBL303832)
Affinity DataKi:  4.20nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068582(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  5nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071348(4-tert-Butyl-N-[5-(1H-imidazol-4-yl)-pentyl]-benze...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071340(CHEMBL68336 | N-[5-(1H-Imidazol-4-yl)-pentyl]-4-ni...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124908(CHEMBL159560 | N-(2-Methoxy-benzyl)-4-trifluoromet...)
Affinity DataKi:  5.70nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071352(CHEMBL69594 | N-[4-(1H-Imidazol-4-yl)-butyl]-C-phe...)
Affinity DataKi:  6nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052511(8-Methyl-3-(2-oxo-propyl)-1-p-tolyl-1,3,8-triaza-s...)
Affinity DataKi:  6.30nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052509(1-Cyclohexylmethyl-8-methyl-3-(2-oxo-propyl)-1,3,8...)
Affinity DataKi:  6.80nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071339(CHEMBL68475 | N-[4-(1H-Imidazol-4-yl)-butyl]-4-tri...)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052514(8-Methyl-3-(2-oxo-propyl)-1-phenyl-1,3,8-triaza-sp...)
Affinity DataKi:  7.70nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212687(2-(3-chloro-benzyl)-5-trifluoromethoxy-2,3-dihydro...)
Affinity DataKi:  8nMAssay Description:Binding affinity to NMDA NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068610(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071358(3-Chloro-N-[4-(1H-imidazol-4-yl)-butyl]-benzenesul...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124892((E)-N-Benzyl-3-phenyl-acrylamidine | CHEMBL158874)
Affinity DataKi:  9nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071346(4-Chloro-N-[4-(1H-imidazol-4-yl)-butyl]-benzenesul...)
Affinity DataKi:  9nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071344(CHEMBL71592 | N-[4-(1H-Imidazol-4-yl)-butyl]-4-tri...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071354(CHEMBL69551 | N-[4-(1H-Imidazol-4-yl)-butyl]-benze...)
Affinity DataKi:  11nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124918(3,4-Dichloro-N-(2-trifluoromethoxy-benzyl)-benzami...)
Affinity DataKi:  12nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071336(4-Chloro-N-[5-(1H-imidazol-4-yl)-pentyl]-benzenesu...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474807(CHEMBL304274)
Affinity DataKi:  15nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50289698(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  15nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124919(3,4-Dichloro-N-(3-chloro-benzyl)-benzamidine | CHE...)
Affinity DataKi:  16nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071351(CHEMBL69456 | N-[4-(1H-Imidazol-4-yl)-butyl]-4-met...)
Affinity DataKi:  17nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071337(CHEMBL69607 | N-[4-(1H-Imidazol-4-yl)-butyl]-4-nit...)
Affinity DataKi:  17nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071356(4-tert-Butyl-N-[4-(1H-imidazol-4-yl)-butyl]-benzen...)
Affinity DataKi:  17nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474794(CHEMBL66539)
Affinity DataKi:  17nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124921(CHEMBL159558 | N-(3-Chloro-benzyl)-4-trifluorometh...)
Affinity DataKi:  20nMAssay Description:Displacement of NMDA receptor-specific [3H]-ifenprodil binding to recombinant human NMDA receptor, NR2B subtype expressed in L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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