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TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239529(CHEMBL4072033)
Affinity DataIC50:  19nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239517(CHEMBL4082508)
Affinity DataIC50:  25nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239516(CHEMBL4060634)
Affinity DataIC50:  34nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239518(CHEMBL4075978)
Affinity DataIC50:  36nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239530(CHEMBL4101470)
Affinity DataIC50:  38nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239519(CHEMBL4091797)
Affinity DataIC50:  41nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239514(CHEMBL4098065)
Affinity DataIC50:  51nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239515(CHEMBL4061657)
Affinity DataIC50:  65nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50153713(3-(N-hydroxyformamido)propylphosphonic acid | 3-[F...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate assessed as formation of MEP measured every 5 secs for 180 secs by spectrophotome...More data for this Ligand-Target Pair
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437793(CHEMBL2407193)
Affinity DataIC50:  140nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239511(CHEMBL4065129)
Affinity DataIC50:  170nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50424783(CHEMBL2315104)
Affinity DataIC50:  240nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239527(CHEMBL4086571)
Affinity DataIC50:  250nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239524(CHEMBL4092758)
Affinity DataIC50:  258nMAssay Description:Binding affinity to Opioid receptor mu 1 in rat brain using [3H]-NAL as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239528(CHEMBL4080038)
Affinity DataIC50:  260nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437797(CHEMBL2407184)
Affinity DataIC50:  320nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239512(CHEMBL4069309)
Affinity DataIC50:  350nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50363052(CHEMBL1946956)
Affinity DataIC50:  400nMAssay Description:Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343344(1-(thiophen-2-ylacetyl)-4-(3-thiophen-2-yl-1,2,4-o...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239513(CHEMBL4090348)
Affinity DataIC50:  502nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239521(CHEMBL4084024)
Affinity DataIC50:  530nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50371060(CHEMBL226646)
Affinity DataIC50:  670nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as ratio of cellular protein product over substrate after 72 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50424783(CHEMBL2315104)
Affinity DataIC50:  750nMAssay Description:Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437803(CHEMBL2407185)
Affinity DataIC50:  830nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343346(4-Methyl-1-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50363017(CHEMBL1945812)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239520(CHEMBL4070933)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343347(2-Cyclopropyl-1-[4-(3-thiophen-2-yl-[1,2,4]oxadiaz...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437792(CHEMBL2407194)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343348(2-Cyclopentyl-1-[4-(3-thiophen-2-yl-[1,2,4]oxadiaz...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343350(4,4,4-trifluoro-1-(4-(3-(thiophen-2-yl)-1,2,4-oxad...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343350(4,4,4-trifluoro-1-(4-(3-(thiophen-2-yl)-1,2,4-oxad...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437806(CHEMBL2407346)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239531(CHEMBL4062310)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343351(4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-ox...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343351(4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-ox...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50422666(CHEMBL607492)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437804(CHEMBL2407348)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50304937(CHEMBL591796 | N-phenethyl-6-(4-(2-(trifluoromethy...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50363015(CHEMBL1945701)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycolicibacterium smegmatis (strain ATCC 700084 / ...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50395186(CHEMBL1612418)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition at EthR in Mycobacterium smegmatis mc2 155 assessed as reactivation of beta-glucuronidase activity measured over 48 hrs by Spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239522(CHEMBL4073664)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343349(2-Cyclohexyl-1-[4-(3-thiophen-2-yl-[1,2,4]oxadiazo...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437805(CHEMBL2407347)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50343345(2-Phenyl-1-[4-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437801(CHEMBL2407188)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437796(CHEMBL2407187)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50437802(CHEMBL2407186)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50363018(CHEMBL1945813)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50239533(CHEMBL4078027)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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