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Found 142 with Last Name = 'lobera' and Initial = 'm'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataIC50:  0.280nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22209(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50112600(CHEMBL3609392)
Affinity DataIC50:  7.90nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22203(1,2,4-oxadiazole based compound, 13 | 1-({4-[3-(4-...)
Affinity DataIC50:  8.20nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50445895(CHEMBL3105674)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287460(CHEMBL4171547)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22203(1,2,4-oxadiazole based compound, 13 | 1-({4-[3-(4-...)
Affinity DataIC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22201(1,3,4-oxadiazole based compound, 9 | 1-({4-[5-(4-t...)
Affinity DataIC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22209(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)
Affinity DataIC50:  12nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50112600(CHEMBL3609392)
Affinity DataIC50:  16nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287460(CHEMBL4171547)
Affinity DataIC50:  16nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287483(CHEMBL4173830)
Affinity DataIC50:  25nMAssay Description:Inverse agonist activity at RORgammat in mouse CD positive T cells assessed as inhibition of Th17 cell differentiation by measuring 1L-17 release aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287483(CHEMBL4173830)
Affinity DataIC50:  32nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287463(CHEMBL4163226)
Affinity DataIC50:  32nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287470(CHEMBL4172665)
Affinity DataIC50:  32nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287483(CHEMBL4173830)
Affinity DataIC50:  32nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287470(CHEMBL4172665)
Affinity DataIC50:  32nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50:  37nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50445895(CHEMBL3105674)
Affinity DataIC50:  40nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287466(CHEMBL4163533)
Affinity DataIC50:  50nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287467(CHEMBL4159083)
Affinity DataIC50:  63nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287469(CHEMBL4166984)
Affinity DataIC50:  79nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287464(CHEMBL4164766)
Affinity DataIC50:  100nMAssay Description:Inverse agonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287466(CHEMBL4163533)
Affinity DataIC50:  100nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22201(1,3,4-oxadiazole based compound, 9 | 1-({4-[5-(4-t...)
Affinity DataIC50:  100nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287467(CHEMBL4159083)
Affinity DataIC50:  126nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287464(CHEMBL4164766)
Affinity DataIC50:  200nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50112600(CHEMBL3609392)
Affinity DataIC50:  200nMAssay Description:Inverse agonist activity at RORgammat in mouse CD positive T cells assessed as inhibition of Th17 cell differentiation by measuring 1L-17 release aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287468(CHEMBL4160934)
Affinity DataIC50: <2.51E+3nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287463(CHEMBL4163226)
Affinity DataIC50: <1.00E+4nMAssay Description:Antagonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bipheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336946(1-((4-(5-(2-Fluorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287469(CHEMBL4166984)
Affinity DataIC50: <1.00E+4nMAssay Description:Antagonist activity at biotinylated RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bipheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335462(1-(4-(5-benzylbenzofuran-2-yl)-3-fluorobenzyl)azet...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287462(CHEMBL4169276)
Affinity DataIC50: <2.51E+4nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287461(CHEMBL4171142)
Affinity DataIC50: <2.51E+4nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50287465(CHEMBL4161349)
Affinity DataIC50: <2.51E+4nMAssay Description:Inverse agonist activity at APC-labeled RORgammat LBD (unknown origin) assessed as inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-bip...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336938(1-((4-(5-(4-Chlorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336939(1-((4-(5-(2,6-Difluorobenzyl)benzo[d]thiazol-2-yl)...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336940(1-(4-(6-Benzylimidazo[1,2-a]pyridin-2-yl)-3-fluoro...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336941(1-(4-(6-Benzyl-1H-benzo[d]imidazol-2-yl)-3-fluorob...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336942(1-(3-Fluoro-4-(5-(3-methylbenzyl)benzo[d]thiazol-2...)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336943(1-(4-(7-Benzylimidazo[1,2-a]pyridin-2-yl)-3-fluoro...)
Affinity DataEC50:  6.09E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336944(1-((4-(5-(2-Chlorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataEC50:  4.88E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336945(1-((4-(5-(3-Chlorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataEC50:  3.88E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336946(1-((4-(5-(2-Fluorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataEC50:  3.47E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335508(1-(4-(6-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  3.47E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336947(1-(4-(6-Benzyl-2H-indazol-2-yl)-3-fluorobenzyl)aze...)
Affinity DataEC50:  2.71E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336948(1-(3-Fluoro-4-(5-(2-methylbenzyl)benzo[d]thiazol-2...)
Affinity DataEC50:  2.44E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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