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Found 224 with Last Name = 'ziegler' and Initial = 'm'
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM1368(9b-(3-methylphenyl)-2H,3H,5H,9bH-isoindolo[1,2-b][...)
Affinity DataIC50:  30nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM1361(9b-(naphthalen-1-yl)-2H,3H,5H,9bH-isoindolo[1,2-b]...)
Affinity DataIC50:  150nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM50010223((S)-7-Allyl-8-methyl-6,7,8,9-tetrahydro-2H-2,7,9a-...)
Affinity DataIC50:  160nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581550(AP-3152 FREE ACID | BMS-986020 | Bms-986020)
Affinity DataIC50:  170nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM1354(9-Phenyl-2,3-Dihydrothiazola[2,3-a]isoindol-5(9bH)...)
Affinity DataIC50:  280nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600721(CHEMBL5184419)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  430nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581550(AP-3152 FREE ACID | BMS-986020 | Bms-986020)
Affinity DataIC50:  570nMAssay Description:Inhibition of OATP1B3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581556(CHEMBL5085260)
Affinity DataIC50:  600nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Mannheim

Curated by ChEMBL
LigandPNGBDBM50033579(16-thia-9-azatetracyclo[7.6.3.02,7.010,15]octadeca...)
Affinity DataIC50:  830nMAssay Description:In vitro for inhibitory activity against HIV-1 Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572210(CHEMBL4846941)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM538213(US11254663, Example 10)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600727(CHEMBL5177647)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600730(CHEMBL5173549)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600731(CHEMBL5178315)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM538299(US11254663, Example 157)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600724(CHEMBL5199184)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572213(CHEMBL4851875)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572215(CHEMBL4875500)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581551(CHEMBL5072201)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572214(CHEMBL4870156)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572218(CHEMBL4872481)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM538513(US11254663, Example 440)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600725(CHEMBL5180682)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600728(CHEMBL5189617)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600725(CHEMBL5180682)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581557(CHEMBL5070789)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581551(CHEMBL5072201)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of OATP1B3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM538277(US11254663, Example 119)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581555(CHEMBL5085115)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572219(CHEMBL4868096)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581550(AP-3152 FREE ACID | BMS-986020 | Bms-986020)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572220(CHEMBL4858615)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50581550(AP-3152 FREE ACID | BMS-986020 | Bms-986020)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600732(CHEMBL5202191)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50581550(AP-3152 FREE ACID | BMS-986020 | Bms-986020)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572218(CHEMBL4872481)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600727(CHEMBL5177647)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572216(CHEMBL4868516)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572213(CHEMBL4851875)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50581550(AP-3152 FREE ACID | BMS-986020 | Bms-986020)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of MRP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572210(CHEMBL4846941)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600728(CHEMBL5189617)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572216(CHEMBL4868516)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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