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Found 661 with Last Name = 'nambi' and Initial = 'p'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85335(SB 234551 | SB-234551)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50061077((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-[2-(2-hydroxy...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041616((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)
Affinity DataKi:  11.3nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  14.7nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041622((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-5-hydroxy-3-(4-...)
Affinity DataKi:  15nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041618((1R,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)
Affinity DataKi:  43nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataKi:  134nMMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061077((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-[2-(2-hydroxy...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041621((1R,2R,3S)-1,3-Bis-(4-methoxy-phenyl)-indan-2-carb...)
Affinity DataKi:  422nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041622((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-5-hydroxy-3-(4-...)
Affinity DataKi:  483nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85335(SB 234551 | SB-234551)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041618((1R,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)
Affinity DataKi:  757nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041616((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)
Affinity DataKi:  1.04E+3nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041621((1R,2R,3S)-1,3-Bis-(4-methoxy-phenyl)-indan-2-carb...)
Affinity DataKi:  2.44E+3nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041619((1S,2S,3R)-1-(4-Methoxy-phenyl)-3-phenyl-indan-2-c...)
Affinity DataKi:  5.67E+3nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041620((1R,2R,3S)-1,3-Diphenyl-indan-2-carboxylic acid | ...)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041620((1R,2R,3S)-1,3-Diphenyl-indan-2-carboxylic acid | ...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041619((1S,2S,3R)-1-(4-Methoxy-phenyl)-3-phenyl-indan-2-c...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of [125I]-ET-1 binding to cloned human ET-B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306072(2-isobutyl-1-(3-(3-(methylsulfonyl)phenoxy)phenyl)...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378590(CHEMBL611735)
Affinity DataIC50:  0.810nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305075(3-benzyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  0.920nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306070(2-isopropyl-1-(3-(3-(methylsulfonyl)phenoxy)phenyl...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306073(1-(3-(3-(methylsulfonyl)phenoxy)phenyl)-2-phenyl-4...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305072(8-chloro-3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306074(2-(4-fluorobenzyl)-1-(3-(3-(methylsulfonyl)phenoxy...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305073(3-benzyl-8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306068(1-(3-(3-(methylsulfonyl)phenoxy)phenyl)-2,4-bis(tr...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20015(2-[4-({[3-(3-benzyl-8-chloroquinolin-4-yl)phenyl]a...)
Affinity DataIC50:  1.40nM EC50:  23nMAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305064(3-(3-(3-(3-methyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20024(2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4...)
Affinity DataIC50:  1.40nM EC50:  316nMAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317735(3-benzyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(t...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306075(4-chloro-2-isopropyl-1-(3-(3-(methylsulfonyl)pheno...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305070(4-(3-(3-(ethylsulfonyl)phenoxy)phenyl)-3-methyl-8-...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317744(4-(4'-fluoro-3'-(methylsulfonyl)biphenyl-3-yl)-3-m...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306069(2-ethyl-1-(3-(3-(methylsulfonyl)phenoxy)phenyl)-4-...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305068(4-(3-(3-(isopropylsulfonyl)phenoxy)phenyl)-3-methy...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317733(3-methyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(t...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20001(2-{4-[({3-[3-benzyl-8-(trifluoromethyl)quinolin-4-...)
Affinity DataIC50:  1.90nM EC50:  33nMAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305060(4-(3-(3-fluoro-5-(methylsulfonyl)phenoxy)phenyl)-3...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20001(2-{4-[({3-[3-benzyl-8-(trifluoromethyl)quinolin-4-...)
Affinity DataIC50:  1.90nM EC50:  33nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35107(biarylether amide quinoline, 4g)
Affinity DataIC50:  1.90nM EC50:  138nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378593(CHEMBL612007)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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