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Found 491 with Last Name = 'drummond' and Initial = 's'
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi:  0.150nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19038(1-(4-methoxyphenyl)-7-oxo-6-{1-[2-(pyrrolidin-1-yl...)
Affinity DataKi:  0.260nM ΔG°:  -54.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19042(6-(1-{2-[(diethylamino)methyl]phenyl}piperidin-4-y...)
Affinity DataKi:  0.260nM ΔG°:  -54.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi:  0.300nMAssay Description:Tested in vitro for inhibition of rabbit Coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19036(6-[1-(2-methanesulfonylphenyl)piperidin-4-yl]-1-(4...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19037(6-(1-{2-[(dimethylamino)methyl]phenyl}piperidin-4-...)
Affinity DataKi:  0.410nM ΔG°:  -53.0kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135953(2-(2-Aminomethyl-phenyl)-5-trifluoromethyl-2H-pyra...)
Affinity DataKi:  0.460nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135943(2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...)
Affinity DataKi:  0.540nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19039(1-(4-methoxyphenyl)-6-{1-[2-(morpholin-4-ylmethyl)...)
Affinity DataKi:  0.570nM ΔG°:  -52.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19032(1-(3-amino-1,2-benzoxazol-5-yl)-N-{1-[2-(pyrrolidi...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19034(1-(3-amino-1,2-benzoxazol-5-yl)-N-(1-{2-[(methylam...)
Affinity DataKi:  0.670nM ΔG°:  -51.8kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19035(1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-{[ethyl(me...)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19033(1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-{[(2R)-2-h...)
Affinity DataKi:  0.730nM ΔG°:  -51.6kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19040(6-[1-(2-{[(2S)-2-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.870nM ΔG°:  -51.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135960(2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...)
Affinity DataKi:  0.880nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135945(1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoyl...)
Affinity DataKi:  0.910nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19041(1-(4-methoxyphenyl)-6-(1-{2-[(methylamino)methyl]p...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002254(2-(1-Benzyl-piperidin-4-yl)-1-(4-fluoro-phenyl)-et...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135966(2-(2-Aminomethyl-phenyl)-5-trifluoromethyl-2H-pyra...)
Affinity DataKi:  1nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19029(1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-methanesul...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135961(2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...)
Affinity DataKi:  1.70nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135951(2-(2-Aminomethyl-phenyl)-5-trifluoromethyl-2H-pyra...)
Affinity DataKi:  1.80nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002207(1-Cyclopropylmethyl-4-(4-fluoro-phenoxymethyl)-pip...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002275(1-Benzyl-4-(3-phenyl-propoxy)-piperidine; compound...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002232(1-Benzyl-4-(4-phenyl-butoxymethyl)-piperidine; hyd...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002235(1-Benzyl-4-(4-trifluoromethyl-phenoxymethyl)-piper...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002209(1-(2,2-Dichloro-1-methyl-cyclopropylmethyl)-4-(4-f...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002219(1-Benzyl-4-cyclopropoxymethyl-piperidine; compound...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002303(1-Cyclopropylmethyl-4-(3,4-difluoro-phenoxymethyl)...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002292(4-[4-(4-Fluoro-benzyloxymethyl)-piperidin-1-ylmeth...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002229(1-Benzyl-4-cyclohexyloxymethyl-piperidine; hydroch...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002190(1-Benzyl-4-(4-fluoro-benzyloxymethyl)-piperidine; ...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002241(1-(4-Chloro-benzyl)-4-(4-fluoro-benzyloxymethyl)-p...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002252(1-Benzyl-4-(4-fluoro-phenoxymethyl)-piperidine; hy...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135954(2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...)
Affinity DataKi:  2.40nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19028(1-[2-(aminomethyl)phenyl]-N-[1-(2-methanesulfonylp...)
Affinity DataKi:  2.40nM ΔG°:  -48.7kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135966(2-(2-Aminomethyl-phenyl)-5-trifluoromethyl-2H-pyra...)
Affinity DataKi:  2.60nMAssay Description:Tested in vitro for inhibition of rabbit Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18965(1-[3-(aminomethyl)phenyl]-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  2.70nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135962(2-(4-Methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole...)
Affinity DataKi:  2.80nMAssay Description:Tested in vitro for inhibition of human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135945(1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoyl...)
Affinity DataKi:  2.90nMAssay Description:Tested in vitro for inhibition of rabbit Coagulation factor XMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002272(1-(2-Cyclopropyl-ethyl)-4-(4-fluoro-phenoxymethyl)...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002280(1-(1-Benzyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-et...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002284(1-Benzyl-4-(4-methoxy-phenoxymethyl)-piperidine | ...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002187(1-(1-Benzyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-et...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002217(2-[1-(4-Fluoro-benzyl)-piperidin-4-yl]-1-(4-fluoro...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002197(1-(1-Benzyl-piperidin-4-yl)-3-(4-fluoro-phenyl)-pr...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002250(1-(4-Fluoro-phenyl)-2-[1-(4-trifluoromethyl-benzyl...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM19024(1-[3-(aminomethyl)phenyl]-N-[4-(2-methanesulfonylp...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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