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Found 179 with Last Name = 'guglielmo' and Initial = 's'
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049873(CHEMBL3322287)
Affinity DataIC50:  10nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049868(CHEMBL3322292)
Affinity DataIC50:  83nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049874(CHEMBL3322286)
Affinity DataIC50:  148nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049872(CHEMBL3322288)
Affinity DataIC50:  316nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049867(CHEMBL3322293)
Affinity DataIC50:  350nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50464816(CHEMBL4285001)
Affinity DataIC50:  370nMAssay Description:Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50464815(CHEMBL4281580)
Affinity DataIC50:  390nMAssay Description:Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  740nMAssay Description:Inhibition of FLAG-tagged HDAC2 (unknown origin) expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50464816(CHEMBL4285001)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50464815(CHEMBL4281580)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC1 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50464816(CHEMBL4285001)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC3 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM50464815(CHEMBL4281580)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC3 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Goethe University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of human FLAG-tagged HDAC3 expressed in HEK293T cells using acetylated lysine side chain as substrate after 1 hr by colorimetric detection...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50038412(2-Oxy-4-phenyl-furazan-3-carbonitrile | 3-cyano-4-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049864(CHEMBL3322356)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50250181(CHEMBL2338421 | N''-(5-Benzofuroxanylmethylidene)I...)
Affinity DataIC50:  1.53E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50250181(CHEMBL2338421 | N''-(5-Benzofuroxanylmethylidene)I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50250181(CHEMBL2338421 | N''-(5-Benzofuroxanylmethylidene)I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50250181(CHEMBL2338421 | N''-(5-Benzofuroxanylmethylidene)I...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50353899(CHEMBL1829095)
Affinity DataIC50:  3.80E+4nMAssay Description:Antagonist activity at thromboxane receptor in human blood assessed as inhibition of U-46619-induced effectMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50353898(CHEMBL1829096)
Affinity DataIC50:  3.90E+4nMAssay Description:Antagonist activity at thromboxane receptor in human blood assessed as inhibition of U-46619-induced effectMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049863(CHEMBL3322357)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049865(CHEMBL3322355)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049866(CHEMBL3322294)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049869(CHEMBL3322291)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049870(CHEMBL3322290)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin glutathione reductase(Schistosoma mansoni)
Universit£

Curated by ChEMBL
LigandPNGBDBM50049871(CHEMBL3322289)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324376(3-Hexyloxy-4-phenylsulfonylfurazan | CHEMBL1215715)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324349(4-amino-3-phenyl-1,2,5-oxadiazole 2-oxide | 5-Oxy-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324355(4-cyano-3-phenyl-1,2,5-oxadiazole 2-oxide | 5-Oxy-...)
Affinity DataEC50:  8.50E+4nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324366(3-Phenylsulfonylfuroxan-4-carboxamide | CHEMBL1215...)
Affinity DataEC50:  8.58E+4nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324350(2-Oxy-4-phenyl-furazan-3-ylamine | 3-amino-4-pheny...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324362(4-Phenylsulfonylfuroxan-3-carboxamide | CHEMBL1215...)
Affinity DataEC50:  1.30E+4nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324368(4-Phenylsulfonylfuroxan-3-carbonitrile | CHEMBL121...)
Affinity DataEC50:  7.20E+4nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324367(3-Phenylsulfonylfuroxan-4-carbonitrile | CHEMBL121...)
Affinity DataEC50:  2.95E+4nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324378(3,4-diphenyl-1,2,5-oxadiazole 2-oxide | CHEMBL1212...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324379(4-methyl-3-phenyl-1,2,5-oxadiazole 2-oxide | CHEMB...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324370(4-Butoxy-3-phenylsulfonylfuroxan | 4-butoxy-3-(phe...)
Affinity DataEC50:  7.61E+3nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324361(3-methyl-4-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxi...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324374(4-Phenyloxy-3-phenylsulfonylfuroxan | CHEMBL121571...)
Affinity DataEC50:  1.36E+4nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324373(4-Isobutoxy-3-phenylsulfonylfuroxan | 4-sec-butoxy...)
Affinity DataEC50:  4.60E+4nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50300754(2-Oxy-4-phenyl-furazan-3-carboxylic acid amide | 3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324375(3-Butoxy-4-phenylsulfonylfurazan | CHEMBL1215714)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324351(4-methoxy-3-phenyl-1,2,5-oxadiazole 2-oxide | CHEM...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324356(3-phenyl-4-sulfamoyl-1,2,5-oxadiazole 2-oxide | CH...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324357(4-phenyl-3-sulfamoyl-1,2,5-oxadiazole 2-oxide | CH...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50001285((E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(...)
Affinity DataEC50:  2.85E+3nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324359(3-Benzenesulfonyl-4-phenyl-furazan 2-oxide | 4-phe...)
Affinity DataEC50:  6.40E+4nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Universita Degli Studi Di Torino

Curated by ChEMBL
LigandPNGBDBM50324371(4-Hexyloxy-3-phenylsulfonylfuroxan | CHEMBL1215644)
Affinity DataEC50:  1.20E+4nMAssay Description:Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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