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Found 1948 with Last Name = 'endo' and Initial = 't'
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  7.44nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262557((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  7.99nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  12.7nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50244419((4bS,8R,8aS,16bR)-7-(cyclopropylmethyl)-5,6,7,8,8a...)
Affinity DataKi:  15.1nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262557((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  23.2nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  27nMAssay Description:Binding affinity to guinea pig mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  30.4nMAssay Description:Binding affinity to guinea pig kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261726((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261791((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50244419((4bS,8R,8aS,16bR)-7-(cyclopropylmethyl)-5,6,7,8,8a...)
Affinity DataKi:  60.6nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261726((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  113nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261791((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262499((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  2.51E+3nMAssay Description:Binding affinity to guinea pig mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50245093((5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  3.29E+3nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261727((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  3.34E+3nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50245093((5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi: >3.67E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262556((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi: >3.67E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261727((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi: >3.67E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262499((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  3.91E+3nMAssay Description:Binding affinity to guinea pig kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262556((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  4.65E+3nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274048(CHEMBL489866 | N-[(5R,6R)-17-(Cyclopropylmethyl)-4...)
Affinity DataIC50:  0.0190nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274519((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.0350nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274401((2E)-N-[(5R,6S)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.0490nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274178((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.0700nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274255((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.100nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274256((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.100nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274175((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.166nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274214((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.230nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274212((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.320nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274349(CHEMBL491075 | N-[(5R,6S)-17-(Cyclopropylmethyl)-4...)
Affinity DataIC50:  0.400nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274348((2E)-N-[(5R,6S)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.420nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274017((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.457nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274177((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.470nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274257((2E)-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-...)
Affinity DataIC50:  0.550nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274016((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.647nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274179((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.75nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM196325(US9212130, I-245)
Affinity DataIC50:  0.800nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274520((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  0.869nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM196345(US9212130, I-265)
Affinity DataIC50:  1nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  1.12nMAssay Description:Agonist activity at kappa opioid receptor in guinea pig ileum assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274213((2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataIC50:  1.60nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM106341(US8575197, II-254)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM106177(US8575197, II-090)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM106178(US8575197, II-091)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM106179(US8575197, II-092)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM106180(US8575197, II-093)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50274775(CHEMBL457735 | N-hexyl-[(5R,6R)-17-(cyclopropylmet...)
Affinity DataIC50:  2nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM196373(US9212130, I-295)
Affinity DataIC50:  2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM196382(US9212130, I-304)
Affinity DataIC50:  2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM196431(US9212130, I-359)
Affinity DataIC50:  2nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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