Affinity DataKi: 0.0700nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 1A receptor by [3H]-8-OH-DPAT displacement.More data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.370nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.510nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.510nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.560nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in human using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.860nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.860nMAssay Description:Binding affinity at 5-HT reuptake site labeled with [3H]-paroxetineMore data for this Ligand-Target Pair
Affinity DataKi: 0.860nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Binding affinity was evaluated at 5-hydroxytryptamine 1A receptor labeled with [3H]-8-OH-DPATMore data for this Ligand-Target Pair
Affinity DataKi: 0.920nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.980nMAssay Description:Inhibition of 5-HT induced [35S]-GTP-gammaS, binding at human cloned 5-HT 1A receptors.More data for this Ligand-Target Pair
Affinity DataKi: 0.990nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Affinity at the 5-HT reuptake site labeled with [3H]-paroxetine using rat frontal cortex membranesMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataKi: 1.05nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:In vitro affinity of the compound at the 5-HT reuptake site using [3H]-paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair