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Found 365 with Last Name = 'duan' and Initial = 'yc'
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594944(CHEMBL5181703)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to GST-tagged EED (unknown origin) assessed as inhibition constant incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM223986((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...)
Affinity DataKi:  11nMAssay Description:Binding affinity to GST-tagged EED (unknown origin) assessed as inhibition constant incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594938(CHEMBL5201204)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594938(CHEMBL5201204)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of His-tagged EED (unknown origin) incubated for 30 mins in presence of biotinylated H3K27me3 peptide (19 to 33 aa) by alpha screening com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM291687(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594945(CHEMBL5180485)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human N-terminal His-6 tagged EED expressed in Escherichia coli strain BL2(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50562610(CHEMBL4779022)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human N-terminal His-6 tagged EED expressed in Escherichia coli strain BL2(DE3) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50:  11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50278274(CHEMBL4166084)
Affinity DataIC50:  12nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582469(CHEMBL5087997)
Affinity DataIC50:  13nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582458(CHEMBL5083395)
Affinity DataIC50:  14nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582461(CHEMBL5093633)
Affinity DataIC50:  15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50278273(CHEMBL4173338)
Affinity DataIC50:  15nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged human HDAC1 expressed in baculovirus expression system using Ac-peptide substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582461(CHEMBL5093633)
Affinity DataIC50:  15nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  16nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged human HDAC1 expressed in baculovirus expression system using Ac-peptide substrate incu...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HDAC2 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence based micr...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594944(CHEMBL5181703)
Affinity DataIC50:  18nMAssay Description:Inhibition of PRC2 complex of EZH2-EED-SUZ12 (unknown origin) using human nucleosome as substrate incubated for 70 mins in presence of [3H]SAMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582456(CHEMBL5081674)
Affinity DataIC50:  19nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594928(CHEMBL5171195)
Affinity DataIC50: <20nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594929(CHEMBL5173010)
Affinity DataIC50: <20nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594930(CHEMBL5188142)
Affinity DataIC50: <20nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594931(CHEMBL5169768)
Affinity DataIC50: <20nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  20nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50611346(CHEMBL5266070)
Affinity DataIC50:  22nMAssay Description:Binding affinity to BRD4 bromodomain 1 in human Ramos cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50278273(CHEMBL4173338)
Affinity DataIC50:  23nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50278274(CHEMBL4166084)
Affinity DataIC50:  25nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582455(CHEMBL5081128)
Affinity DataIC50:  28nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  28nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mi...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582457(CHEMBL5087466)
Affinity DataIC50:  34nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  45nMAssay Description:Inhibition of full length N-terminal His-6x tagged EED (1 to 441 residues) (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582454(CHEMBL5075646)
Affinity DataIC50:  47nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582467(CHEMBL5085680)
Affinity DataIC50:  54nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM291687(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of EED (unknown origin) by alpha screen binding assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataIC50:  74nMAssay Description:Inhibition of BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50582470(CHEMBL5081983)
Affinity DataIC50:  93nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataIC50:  94nMAssay Description:Inhibition of MAOB (unknown origin) using beetle luciferin as substrate by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594935(CHEMBL5205261)
Affinity DataIC50: <100nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594936(CHEMBL5206890)
Affinity DataIC50: <100nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594937(CHEMBL5180270)
Affinity DataIC50: <100nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594933(CHEMBL5193972)
Affinity DataIC50: <100nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594934(CHEMBL5171965)
Affinity DataIC50: <100nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Sanquan College Of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50594932(CHEMBL5203240)
Affinity DataIC50: <100nMAssay Description:Inhibition of EED (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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