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Found 263 with Last Name = 'anderson' and Initial = 'mk'
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051456(CHEMBL306344 | N-(2,6-Diisopropyl-phenyl)-2-(2-dod...)
Affinity DataIC50:  10nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051460(2-(2-Dodecyl-2H-tetrazol-5-yl)-2-phenyl-N-(2,4,6-t...)
Affinity DataIC50:  14nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053404(CHEMBL340148 | N-(2,6-Diisopropyl-phenyl)-2-(5-dod...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053395(2-(3-Dodecyl-isoxazol-5-yl)-2-phenyl-N-(2,4,6-trim...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287512(3-(2,6-Diisopropyl-phenyl)-1-phenyl-1-{2-[8-(tetra...)
Affinity DataIC50:  16nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053394(2-(5-Dodecyl-[1,3,4]oxadiazol-2-yl)-2-phenyl-N-(2,...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053399(CHEMBL339119 | N-(2,6-Diisopropyl-phenyl)-2-(3-dod...)
Affinity DataIC50:  19nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053398(2-(5-Dodecyl-isoxazol-3-yl)-2-phenyl-N-(2,4,6-trim...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053406(2-(4-Dodecyl-[1,2,3]triazol-1-yl)-2-phenyl-N-(2,4,...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450396(CHEMBL102912)
Affinity DataIC50:  22nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051460(2-(2-Dodecyl-2H-tetrazol-5-yl)-2-phenyl-N-(2,4,6-t...)
Affinity DataIC50:  24nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051460(2-(2-Dodecyl-2H-tetrazol-5-yl)-2-phenyl-N-(2,4,6-t...)
Affinity DataIC50:  24nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053407(CHEMBL338751 | N-(2,6-Diisopropyl-phenyl)-2-(5-dod...)
Affinity DataIC50:  24nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053400(2-(3-Dodecyl-[1,2,4]oxadiazol-5-yl)-2-phenyl-N-(2,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053405(2-(5-Dodecyl-[1,2,4]oxadiazol-3-yl)-2-phenyl-N-(2,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287511(1-Cyclohexyl-3-(2,6-diisopropyl-phenyl)-1-(2-dodec...)
Affinity DataIC50:  31nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053392(2-(3-Dodecyl-isoxazol-5-yl)-N-(2,4,6-trimethoxy-ph...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287513(1-Benzyl-1-(2-dodecyl-2H-tetrazol-5-yl)-3-(2,4,6-t...)
Affinity DataIC50:  35nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287509(1-[2-(10-Methyl-undecyl)-2H-tetrazol-5-yl]-1-pheny...)
Affinity DataIC50:  40nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287515(1-Phenyl-1-{2-[8-(tetrahydro-pyran-2-yloxy)-octyl]...)
Affinity DataIC50:  41nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053393(2-(4-Dodecyl-pyrazol-1-yl)-2-phenyl-N-(2,4,6-trime...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287517(3-(2,6-Diisopropyl-phenyl)-1-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50:  47nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053403(CHEMBL125407 | N-(2,4-Difluoro-phenyl)-2-(3-dodecy...)
Affinity DataIC50:  51nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450398(CHEMBL100448)
Affinity DataIC50:  52nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287514(1-Cyclohexyl-1-(2-dodecyl-2H-tetrazol-5-yl)-3-(2,4...)
Affinity DataIC50:  57nMAssay Description:Liver ACAT inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from the livers of cholesterol fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287518(1-(2-Dodecyl-2H-tetrazol-5-yl)-1-phenyl-3-(2,4,6-t...)
Affinity DataIC50:  61nMAssay Description:Liver ACAT inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from the livers of cholesterol fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287516(1-Phenyl-1-(2-tetradecyl-2H-tetrazol-5-yl)-3-(2,4,...)
Affinity DataIC50:  71nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450397(CHEMBL103748)
Affinity DataIC50:  79nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450390(CHEMBL99056)
Affinity DataIC50:  80nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450384(CHEMBL317244)
Affinity DataIC50:  80nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285512(CHEMBL77612 | N-{[(2,4,6-trimethoxyphenyl)amino]ca...)
Affinity DataIC50:  85nMAssay Description:Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in liver microsomes of cholesterol fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50285501(CHEMBL77898 | N-{[(2,6-isopropylphenyl)amino]carbo...)
Affinity DataIC50:  86nMAssay Description:Inhibition of Acyl-CoA: Cholesterol Acyltransferase (ACAT) in intestinal microsomes of cholesterol fed rabbitsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053396(1-(5-Dodecyl-isoxazol-3-yl)-cyclopentanecarboxylic...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053401(CHEMBL129811 | N-(2,4-Difluoro-phenyl)-2-(5-dodecy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50050259(CHEMBL277001 | N'-[2,6-Bis(1-methylethyl)phenyl]-N...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053397(2-(4-Dodecyl-imidazol-1-yl)-2-phenyl-N-(2,4,6-trim...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50:  110nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50286270(CHEMBL100697 | N-[(2-Dodecyl-2H-tetrazol-5-yl)-phe...)
Affinity DataIC50:  110nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in intestinal microsomes isolated from chole...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50:  110nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450382(CHEMBL101629)
Affinity DataIC50:  120nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50050274(CHEMBL281597 | N'-[2,6-Bis(1-methylethyl)phenyl]-N...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450380(CHEMBL100936)
Affinity DataIC50:  140nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50053402(2-(5-Dodecyl-isoxazol-3-yl)-N-(2,4,6-trimethoxy-ph...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450395(CHEMBL318600)
Affinity DataIC50:  160nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450389(CHEMBL318373)
Affinity DataIC50:  180nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450386(CHEMBL98716)
Affinity DataIC50:  190nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50050223(CHEMBL22476 | N'-[2,6-Bis(1-methylethyl)phenyl]-N-...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50050228(CHEMBL284003 | N'-[2,6-Bis(1-methylethyl)phenyl]-N...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287517(3-(2,6-Diisopropyl-phenyl)-1-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50:  240nMAssay Description:Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50450394(CHEMBL101601)
Affinity DataIC50:  240nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails Article
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