Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50286270
Substrate
n/a
Meas. Tech.
ChEMBL_28182 (CHEMBL639299)
IC50
110±n/a nM
Citation
 O'Brien, PM; Sliskovic, DR; Anderson, MK; Bousley, RF; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 12. Syntheses and biological activity of structurally novel tetrazole amides Bioorg Med Chem Lett 5:289-294 (1995)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50286270
Synonyms:
CHEMBL100697 | N-[(2-Dodecyl-2H-tetrazol-5-yl)-phenyl-methyl]-2,6-dimethyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C29H41N5O
Mol. Mass.:
475.6687
SMILES:
CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1c(C)cccc1C)c1ccccc1
Structure:
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