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Found 49 with Last Name = 'arduini' and Initial = 'rm'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: <1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: <1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610139(CHEMBL5287698)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610137(CHEMBL5269111)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610128(CHEMBL5284310)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610138(CHEMBL5268773)
Affinity DataIC50:  3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610129(CHEMBL5276931)
Affinity DataIC50:  5nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610134(CHEMBL5280787)
Affinity DataIC50:  5nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610127(CHEMBL5269279)
Affinity DataIC50:  7nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610126(CHEMBL5266943)
Affinity DataIC50:  9nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50588008(CHEMBL5196798)
Affinity DataIC50:  13nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610141(CHEMBL5274934)
Affinity DataIC50:  15nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610119(CHEMBL5285015)
Affinity DataIC50:  20nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610125(CHEMBL5276135)
Affinity DataIC50:  22nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610124(CHEMBL5274214)
Affinity DataIC50:  43nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610131(CHEMBL5289054)
Affinity DataIC50:  45nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610132(CHEMBL5290011)
Affinity DataIC50:  45nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610142(CHEMBL5286967)
Affinity DataIC50:  49nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610123(CHEMBL5276339)
Affinity DataIC50:  53nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610135(CHEMBL5267533)
Affinity DataIC50:  58nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610117(CHEMBL5269357)
Affinity DataIC50:  80nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610120(CHEMBL5286154)
Affinity DataIC50:  110nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610130(CHEMBL5276857)
Affinity DataIC50:  180nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610121(CHEMBL5274555)
Affinity DataIC50:  220nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610122(CHEMBL5289459)
Affinity DataIC50:  270nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610118(CHEMBL5273873)
Affinity DataIC50:  380nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610115(CHEMBL5275020)
Affinity DataIC50:  650nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610116(CHEMBL5270872)
Affinity DataIC50:  890nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610112(CHEMBL5266996)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610114(CHEMBL5266164)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610113(CHEMBL5289611)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610133(CHEMBL5290736)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 2C19(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 30 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 2C19(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 30 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610111(CHEMBL5279801)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analys...More data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analys...More data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Ligand Info
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of Transforming growth factor beta-1 receptor (TbetaRI) autophosphorylationMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Transforming growth factor beta-1 receptor (TbetaRI)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataKd:  5nMAssay Description:Dissociation constant for TGF-beta receptor type IMore data for this Ligand-Target Pair