Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM21492
Substrate
n/a
Meas. Tech.
ChEMBL_208099 (CHEMBL814455)
Kd
5±n/a nM
Citation
Singh, J; Chuaqui, CE; Boriack-Sjodin, PA; Lee, WC; Pontz, T; Corbley, MJ; Cheung, HK; Arduini, RM; Mead, JN; Newman, MN; Papadatos, JL; Bowes, S; Josiah, S; Ling, LE Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett 13:4355-9 (2003) [PubMed] Article
More Info.:
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Inhibitor
Name:
BDBM21492
Synonyms:
4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CHEMBL261454 | LY364947 | US11759530, Compound Table1.1 | US9138393, LY-364947 | US9144538, LY-364947
Type:
Small organic molecule
Emp. Form.:
C17H12N4
Mol. Mass.:
272.304
SMILES:
c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1