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Found 213 with Last Name = 'argade' and Initial = 'a'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50249090(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Affinity DataKi:  96nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255524(N4-[(2,2-Difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]...)
Affinity DataIC50:  0.450nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataIC50:  0.450nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234969(US9556148, 40 | n-(cyanomethyl)-4-(5-methyl-2-((4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600312(CHEMBL5189266)
Affinity DataIC50:  1nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600312(CHEMBL5189266)
Affinity DataIC50:  3nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234969(US9556148, 40 | n-(cyanomethyl)-4-(5-methyl-2-((4-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234973(US9556148, 44 | n-(cyanomethyl)-4-(5-fluoro-2-((4-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234957(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234968(4-(2-((4-(4-(6-acetyl-3,6-diazabicyclo[3.1.1]hepta...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234959(US9556148, 27 | n-(cyanomethyl)-4-(2-((4-(4-(tetra...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234957(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234973(US9556148, 44 | n-(cyanomethyl)-4-(5-fluoro-2-((4-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234946(US9556148, 3 | n-(cyanomethyl)-4-(2-((4-(4-morphol...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234954(4-(2-((4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600312(CHEMBL5189266)
Affinity DataIC50:  9nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234968(4-(2-((4-(4-(6-acetyl-3,6-diazabicyclo[3.1.1]hepta...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234959(US9556148, 27 | n-(cyanomethyl)-4-(2-((4-(4-(tetra...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600306(CHEMBL5201856)
Affinity DataIC50:  10nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255515(US10828301, Compound R950368 | US9499493, R950368)
Affinity DataIC50:  10.7nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255515(US10828301, Compound R950368 | US9499493, R950368)
Affinity DataIC50:  10.7nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234969(US9556148, 40 | n-(cyanomethyl)-4-(5-methyl-2-((4-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234946(US9556148, 3 | n-(cyanomethyl)-4-(2-((4-(4-morphol...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255514(US10828301, Compound R921304 | US9499493, R921304)
Affinity DataIC50:  12.8nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255514(US10828301, Compound R921304 | US9499493, R921304)
Affinity DataIC50:  12.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234954(4-(2-((4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234973(US9556148, 44 | n-(cyanomethyl)-4-(5-fluoro-2-((4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234948(4-(2-((4-(4-(1h-1,2,4-triazol-1-yl)piperidin-1-yl)...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600308(CHEMBL5174885)
Affinity DataIC50:  18nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234948(4-(2-((4-(4-(1h-1,2,4-triazol-1-yl)piperidin-1-yl)...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600308(CHEMBL5174885)
Affinity DataIC50:  22nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255518((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...)
Affinity DataIC50:  24nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471742((+/−)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-...)
Affinity DataIC50:  24nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255508(US10828301, Compound R935302 | US9499493, R935302)
Affinity DataIC50:  26.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255508(US10828301, Compound R935302 | US9499493, R935302)
Affinity DataIC50:  26.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255513(US10828301, Compound R940338 | US9499493, R940338)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255513(US10828301, Compound R940338 | US9499493, R940338)
Affinity DataIC50:  28nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471768(N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...)
Affinity DataIC50:  34.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255525(N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...)
Affinity DataIC50:  34.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600306(CHEMBL5201856)
Affinity DataIC50:  35nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471741(N4-(1,4-Benzoxazine-3-on-6-yl)-5-fluoro-N2-(3-hydr...)
Affinity DataIC50:  37.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255501(US9499493, R908702)
Affinity DataIC50:  37.8nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255509(US10828301, Compound R935304 | US9499493, R935304)
Affinity DataIC50:  42nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255509(US10828301, Compound R935304 | US9499493, R935304)
Affinity DataIC50:  42nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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