BindingDB PrimarySearch_ki

Found 230 with Last Name = 'asada' and Initial = 'n'

Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50505569(CHEMBL4557670)

Ki: 0.120nMAssay Description:Displacement of [3H] JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM210070(US9270353, 17)

Ki: 0.130nMAssay Description:Displacement of [3H] JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50580217(CHEMBL5093195)

Ki: 0.290nMAssay Description:Binding affinity to BACE2 (unknown origin)More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50505569(CHEMBL4557670)

Ki: 0.340nMAssay Description:Displacement of [3H] JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50580216(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)

Ki: 0.400nMAssay Description:Displacement of [3H] JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50580217(CHEMBL5093195)

Ki: 0.690nMAssay Description:Binding affinity to BACE1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50579805(CHEMBL5075689)

Ki: 0.800nMAssay Description:Displacement of [3H] JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501808(CHEMBL4465534)

Ki: 1.90nMAssay Description:Displacement of [3H]-JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50570460(CHEMBL4854629)

Ki: 3.5nMAssay Description:Displacement of [3H]-JNJ962 from BACE1 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501810(CHEMBL4443968)

Ki: 4nMAssay Description:Displacement of [3H]-JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair

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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501818(CHEMBL4583340)

Ki: 6.5nMAssay Description:Displacement of [3H]-JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair

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Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50579805(CHEMBL5075689)

Ki: 9.60nMAssay Description:Displacement of [3H] JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50580216(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)

Ki: 11nMAssay Description:Displacement of [3H] JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM210070(US9270353, 17)

Ki: 185nMAssay Description:Displacement of [3H] JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair

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Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501818(CHEMBL4583340)

Ki: 479nMAssay Description:Displacement of [3H]-JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50570460(CHEMBL4854629)

Ki: 1.09E+3nMAssay Description:Displacement of [3H]-JNJ962 from BACE2 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501808(CHEMBL4465534)

Ki: 1.74E+3nMAssay Description:Displacement of [3H]-JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Beta-secretase 2(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501810(CHEMBL4443968)

Ki: 2.00E+3nMAssay Description:Displacement of [3H]-JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair

PDB
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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593249(CHEMBL5199870)

IC50: 0.210nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593251(CHEMBL5199920)

IC50: 0.280nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593248(CHEMBL5208859)

IC50: 0.290nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593250(CHEMBL5180391)

IC50: 0.370nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50505569(CHEMBL4557670)

IC50: 0.380nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wildtype APP assessed as reduction in amyloid beta 42 levelMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50505569(CHEMBL4557670)

IC50: 0.380nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing human wild type amyloid precursor protein assessed as reduction in amyloidbeta40 production inc...More data for this Ligand-Target Pair

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3D Structure (crystal)

Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593258(CHEMBL5175402)

IC50: 0.440nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593247(CHEMBL5194642)

IC50: 0.450nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM204940(I-25)

IC50: 0.580nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild-type human beta-APP assessed as reduction in secreted amyloid beta (1 to 40) after 24 hrs b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593255(CHEMBL5201455)

IC50: 0.620nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50567456(CHEMBL4865251)

IC50: 0.620nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501811(CHEMBL4535964)

IC50: 0.630nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593245(CHEMBL5195759)

IC50: 0.680nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593246(CHEMBL5183416)

IC50: 0.780nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50567457(CHEMBL4866376)

IC50: 0.840nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50432632(CHEMBL2347211)

IC50: 0.930nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing APP695 assessed as reduction in Abeta42 level measured after 18 hrs by sandwich ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50579805(CHEMBL5075689)

IC50: 0.930nMAssay Description:Inhibition of BACE1 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501811(CHEMBL4535964)

IC50: 0.930nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing APP695 assessed as reduction in Abeta42 level measured after 18 hrs by sandwich ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Shionogi

Curated by ChEMBL

PNG

BDBM50593257(CHEMBL5203523)

IC50: 0.990nMAssay Description:Inhibition of HIV-1 protease using EDANS-RESGIFLETSKR-DABCYL as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50505569(CHEMBL4557670)

IC50: 1nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wildtype APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by sandwich Alp...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50462004(CHEMBL4226007)

IC50: 1.10nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild-type human beta-APP assessed as reduction in secreted amyloid beta (1 to 40) after 24 hrs b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50580213(CHEMBL5093159)

IC50: 1.10nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wildtype APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by sandwich Alp...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM210070(US9270353, 17)

IC50: 1.10nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM210091(US9270353, 50)

IC50: 1.10nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501814(CHEMBL4592239)

IC50: 1.20nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing APP695 assessed as reduction in Abeta42 level measured after 18 hrs by sandwich ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM204994(I-27)

IC50: 1.5nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild-type human beta-APP assessed as reduction in secreted amyloid beta (1 to 40) after 24 hrs b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM116292(US8637504, 59 | US9273053, 59 | US9650371, 59)

IC50: 1.60nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing wild type betaAPP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 2...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50462005(CHEMBL4227313)

IC50: 1.60nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild-type human beta-APP assessed as reduction in secreted amyloid beta (1 to 40) after 24 hrs b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50462001(CHEMBL4227054)

IC50: 1.70nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild-type human beta-APP assessed as reduction in secreted amyloid beta (1 to 40) after 24 hrs b...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501806(CHEMBL4473080)

IC50: 1.70nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using Mca-APP Swedish Lys-Met/Asn-Leu mutant-Dnp quencher as substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM50501816(CHEMBL4568202)

IC50: 1.80nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing APP695 assessed as reduction in Abeta42 level measured after 18 hrs by sandwich ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Beta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

PNG

BDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)

IC50: 1.90nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 230 total ) | Next | Last >>

Filter my 230 hits

Targets 12▿
- Beta-secretase 1 116
- Beta-secretase 2 41
- Gag-Pol polyprotein [489-587] 23
- Kinesin-like protein KIF11 19
- Cytochrome P450 2D6 17
- Cathepsin D 4
- Cytochrome P450 2C9 3
- Potassium voltage-gated channel subfamily H member 2 2
- Cytochrome P450 3A4 2
- Cytochrome P450 1A2 1
- Cathepsin E 1
- Cytochrome P450 2C19 1
- ...
Publications 9▿
- J Med Chem 62: 5080-5095 (2019) 51
- J Med Chem 61: 5525-5546 (2018) 47
- J Med Chem 64: 1873-1888 (2021) 37
- J Med Chem 64: 14165-14174 (2021) 27
- J Med Chem 54: 4839-46 (2011) 19
- J Med Chem 64: 3075-3085 (2021) 18
- ACS Med Chem Lett 13: 1634-1641 (2022) 16
- J Med Chem 62: 9331-9337 (2019) 8
- J Med Chem 65: 6157-6170 (2022) 7
Institutions 5▿
- TBA 106
- Shionogi Pharmaceutical Research Center 52
- Janssen Research & Development 37
- Kyoto University 19
- Shionogi 16
Affinity: 0.12 to 1.0E+5 nM▿
- Ki 18
- IC50 212
- Affinity ≤ nM
Xtal structures: 18
Docked structures: 0
Catalog Cmpds: 12