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Found 7 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50505569'
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H] JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing human wild type amyloid precursor protein assessed as reduction in amyloidbeta40 production inc...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wildtype APP assessed as reduction in amyloid beta 42 levelMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataIC50:  1nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wildtype APP assessed as reduction in amyloid beta 42 level incubated for 18 hrs by sandwich Alp...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of BACE1 (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human BACE1 incubated for 3 hrs using APP derived peptide as substrate by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50505569(CHEMBL4557670)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACE1 (unknown origin) by biochemical homogeneous time-resolved fluorescence based assayMore data for this Ligand-Target Pair