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Found 390 with Last Name = 'atkinson' and Initial = 'l'
TargetProline racemase(Clostridium sticklandii)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50444845(CHEMBL1235532)
Affinity DataKi:  5.80E+3nMAssay Description:Competitive inhibition of N-terminal 6xHis-tagged Clostridium sticklandii ATCC 12662 proline racemase expressed in Escherichia coli BL21(DE3) using L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMandelate racemase(Pseudomonas putida (g-Proteobacteria))
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM81768(BENZYLIC ACID | CAS_6581-06-2 | NSC_5311391 | Quin...)
Affinity DataKi:  7.00E+5nMAssay Description:Competitive inhibition of Pseudomonas putida mandelate racemaseMore data for this Ligand-Target Pair
TargetProline racemase(Clostridium sticklandii)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50444846(CHEMBL3099361)
Affinity DataKi:  1.11E+8nMAssay Description:Noncompetitive inhibition of N-terminal 6xHis-tagged Clostridium sticklandii ATCC 12662 proline racemase expressed in Escherichia coli BL21(DE3) usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Schizosaccharomyces pombe (strain 972 / ATCC 24843...)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50444848(CHEMBL3099359)
Affinity DataKi:  1.67E+8nMAssay Description:Mixed type inhibition of N-terminal 6xHis-tagged recombinant Schizosaccharomyces pombe 972 serine racemase expressed in Escherichia coli BL21(DE3) us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Schizosaccharomyces pombe (strain 972 / ATCC 24843...)
Dalhousie University

Curated by ChEMBL
LigandPNGBDBM50444848(CHEMBL3099359)
Affinity DataKi:  6.61E+8nMAssay Description:Mixed type inhibition of N-terminal 6xHis-tagged recombinant Schizosaccharomyces pombe 972 serine racemase expressed in Escherichia coli BL21(DE3) us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50172920(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Affinity DataIC50:  1.26nMAssay Description:Inhibition of JNK3 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50172920(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Affinity DataIC50:  3.98nMAssay Description:Inhibition of p38alpha by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419265(CHEMBL1835069)
Affinity DataIC50:  4nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178832(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of JNK3 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419258(CHEMBL1835070)
Affinity DataIC50:  10nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419256(CHEMBL1835065 | US9579320, Example 302)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  16nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419256(CHEMBL1835065 | US9579320, Example 302)
Affinity DataIC50:  20nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419263(CHEMBL1835057)
Affinity DataIC50:  25nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419247(CHEMBL1835071 | US8470835, 1)
Affinity DataIC50:  32nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467637(CHEMBL4287010)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467650(CHEMBL4282883)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419247(CHEMBL1835071 | US8470835, 1)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:Recombinant human Syk was express as a His-tagged protein. The activity of Syk was asses using a time-resolved fluorescence resonance entery transfe...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415616(CHEMBL1087421)
Affinity DataIC50:  50.1nMAssay Description:Inhibition of N-terminal histidine-tagged human full length JNK3 by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419265(CHEMBL1835069)
Affinity DataIC50:  63nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50249287(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
Affinity DataIC50:  63nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467644(CHEMBL4281286)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467630(CHEMBL4291402)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419260(CHEMBL1834758)
Affinity DataIC50:  79nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467636(CHEMBL4289500)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419247(CHEMBL1835071 | US8470835, 1)
Affinity DataIC50:  79nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419258(CHEMBL1835070)
Affinity DataIC50:  79nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419255(CHEMBL1835064)
Affinity DataIC50:  79nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50172920(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Affinity DataIC50:  79.4nMAssay Description:Inhibition of JNK1 by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467649(CHEMBL4283403)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419262(CHEMBL1835068)
Affinity DataIC50:  100nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415620(CHEMBL1088633)
Affinity DataIC50:  126nMAssay Description:Inhibition of N-terminal histidine-tagged human full length JNK3 by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419253(CHEMBL1835061)
Affinity DataIC50:  126nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419250(CHEMBL1834757)
Affinity DataIC50:  126nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467637(CHEMBL4287010)
Affinity DataIC50:  126nMAssay Description:Inhibition of SYK in human Ramos B cells assessed as reduction in anti-human IgM Fab2 fragment-induced ERK phosphorylation preincubated for 30 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419259(CHEMBL1835072)
Affinity DataIC50:  126nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419259(CHEMBL1835072)
Affinity DataIC50:  126nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419260(CHEMBL1834758)
Affinity DataIC50:  126nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419250(CHEMBL1834757)
Affinity DataIC50:  158nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467633(CHEMBL4291945)
Affinity DataIC50:  158nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467641(CHEMBL4281815)
Affinity DataIC50:  158nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419253(CHEMBL1835061)
Affinity DataIC50:  200nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50467633(CHEMBL4291945)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM86638
Affinity DataIC50:  200nMAssay Description:Inhibition of human truncated JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467630(CHEMBL4291402)
Affinity DataIC50:  200nMAssay Description:Inhibition of SYK in human Ramos B cells assessed as reduction in anti-human IgM Fab2 fragment-induced ERK phosphorylation preincubated for 30 mins f...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467675(CHEMBL4280620)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467663(CHEMBL4285153)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467665(CHEMBL4287765)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178832(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of p38alpha by high throughput screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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