Compile Data Set for Download or QSAR
maximum 50k data
Found 507 with Last Name = 'atkinson' and Initial = 'rn'
TargetKappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  0.00600nMAssay Description:Antagonist activity on agonist (U50,488) stimulated [35S]GTP-gamma-S, binding in cloned opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143320((+)-epibatidine | (-)-1-epidatidine | (1S,2S,4R)-2...)
Affinity DataKi:  0.0260nMAssay Description:Displacement of [3H]epibatidine from alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.0380nMAssay Description:Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50079453(2-(6-Chloro-pyridin-3-yl)-7-methyl-7-aza-bicyclo[2...)
Affinity DataKi:  0.0380nMAssay Description:Displacement of [3H]epibatidine from alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  0.0530nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50027039(5''-Guanidinonaltrindole | 5''-Guanidinylnaltrindo...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.320nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to opioid receptor kappa 1 of guinea pig brain, using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50027052(CHEMBL2112473)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.910nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.960nMAssay Description:Binding affinity towards human cloned Opioid receptor mu 1 using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  1.09nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  1.09nMAssay Description:Ability to displace [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]epibatidine from alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.57nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.60nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50027052(CHEMBL2112473)
Affinity DataKi:  1.80nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50098462(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-hydroxy-ph...)
Affinity DataKi:  1.85nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130561((R)-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dime...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130561((R)-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dime...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (DAMGO, mu-receptor), in guinea pig caudate membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089153(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Affinity DataKi:  3.28nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50116621(3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...)
Affinity DataKi:  3.30nMAssay Description:Ability to displace [3H]DAMGO from Opioid receptor mu 1 of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089153(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Affinity DataKi:  3.30nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  3.40nMAssay Description:Antagonist activity on agonist (DAMGO) stimulated [35S]GTP-gamma-S, binding in cloned mu opioid receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089156(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Affinity DataKi:  3.5nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089156(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Affinity DataKi:  3.51nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089154(4-[[((Z)-8-But-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-y...)
Affinity DataKi:  3.70nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to mu-opioid receptor of rat brain using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50027052(CHEMBL2112473)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards human cloned Opioid receptor mu 1 using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102710(3-(4-Hydroxy-phenyl)-N-{(S)-1-[(3R,4R)-4-(3-hydrox...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to opioid receptor kappa 1 of guinea pig brain, using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102710(3-(4-Hydroxy-phenyl)-N-{(S)-1-[(3R,4R)-4-(3-hydrox...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50116622(CHEMBL117457 | N-[5-(3-Hydroxy-phenyl)-4-methyl-2-...)
Affinity DataKi:  4.30nMAssay Description:Ability to displace [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102710(3-(4-Hydroxy-phenyl)-N-{(S)-1-[(3R,4R)-4-(3-hydrox...)
Affinity DataKi:  4.70nMAssay Description:inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50116624(3-Guanidino-N-[5-(3-hydroxy-phenyl)-4-methyl-2-phe...)
Affinity DataKi:  5.20nMAssay Description:Ability to displace [3H]DAMGO from Opioid receptor mu 1 of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50083637(4-(((3S,4R)-1-allyl-3-methylpiperidin-4-yl)(phenyl...)
Affinity DataKi:  5.58nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50083637(4-(((3S,4R)-1-allyl-3-methylpiperidin-4-yl)(phenyl...)
Affinity DataKi:  5.58nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50082341(4-[((3R,4S)-1-Allyl-3-methyl-piperidin-4-yl)-pheny...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  5.70nMAssay Description:Binding affinity towards human cloned Opioid receptor delta 1 using [3H]Cl-DPDPEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50083637(4-(((3S,4R)-1-allyl-3-methylpiperidin-4-yl)(phenyl...)
Affinity DataKi:  5.90nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50102710(3-(4-Hydroxy-phenyl)-N-{(S)-1-[(3R,4R)-4-(3-hydrox...)
Affinity DataKi:  7.30nMAssay Description:inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (DAMGO, mu-receptor), in guinea pig caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  8.90nMAssay Description:Binding affinity towards human cloned Opioid receptor mu 1 using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130564(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  9.80nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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