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Found 129 with Last Name = 'auger' and Initial = 'kr'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  66nMpH: 6.8Assay Description:wild-type HCT116 selected at 6WT-6x the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  109nMpH: 6.8Assay Description:wild-type HCT116 selected at 3 the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  120nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.180nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.200nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.230nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.300nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.310nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.350nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  0.450nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  0.460nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.590nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  0.720nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  0.830nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  1nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  3.30nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
LigandPNGBDBM50091692(CHEMBL3582357)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  6.90nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  8.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  10nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220195(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50:  13nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220159(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220185(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091694(CHEMBL3582359)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091694(CHEMBL3582359)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091694(CHEMBL3582359)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  22nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220201(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091694(CHEMBL3582359)
Affinity DataIC50:  25nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220155(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091697(CHEMBL3582353)
Affinity DataIC50:  30nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220176(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
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