Compile Data Set for Download or QSAR
maximum 50k data
Found 1766 with Last Name = 'bärfacker' and Initial = 'l'
TargetProthrombin(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50443853(CHEMBL3091519 | US20230391761, Reference 1)
Affinity DataIC50:  0.190nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227802(US10047096, 65 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50:  0.246nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227931(US10047096, 192 | trans-Ethyl 3-[({4-[(2-fluoro-5-...)
Affinity DataIC50:  0.274nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227801(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Affinity DataIC50:  0.287nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227926(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Affinity DataIC50:  0.325nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227794(US10047096, 57 | rac-1-({4-[(2-Fluoro-5-hydroxy-4-...)
Affinity DataIC50:  0.330nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227785(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(i...)
Affinity DataIC50:  0.363nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227814(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Affinity DataIC50:  0.372nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227902(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[4...)
Affinity DataIC50:  0.388nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227786(8-{[Ethyl(methyl)amino]methyl}-4-[(2-fluoro-5-hydr...)
Affinity DataIC50:  0.388nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227799(US10047096, 62 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Affinity DataIC50:  0.394nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227765(8-[(Diethylamino)methyl]-4-[(2-fluoro-5-hydroxy-4-...)
Affinity DataIC50:  0.401nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227906(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Affinity DataIC50:  0.407nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227930(US10047096, 191 | cis-Ethyl 3-[({4-[(2-fluoro-5-hy...)
Affinity DataIC50:  0.419nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227816(8-{[(1,3-Dihydroxypropan-2-yl)amino]methyl}-4-[(2-...)
Affinity DataIC50:  0.429nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50443853(CHEMBL3091519 | US20230391761, Reference 1)
Affinity DataIC50:  0.430nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227796(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(3...)
Affinity DataIC50:  0.432nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227768(8-[(Ethylamino)methyl]-4-[(2-fluoro-5-hydroxy-4-me...)
Affinity DataIC50:  0.448nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639340(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-{[(5-chloro-2...)
Affinity DataIC50:  0.450nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227812(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({[...)
Affinity DataIC50:  0.459nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227771(8-[(Cyclopentylamino)methyl]-4-[(2-fluoro-5-hydrox...)
Affinity DataIC50:  0.472nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227792(8-{[Ethyl(2-methoxyethyl)amino]methyl}-4-[(2-fluor...)
Affinity DataIC50:  0.473nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227812(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({[...)
Affinity DataIC50:  0.475nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639343(3-(1-Methyl-1H-imidazol-2-yl)propyl 3-[(5-chloroth...)
Affinity DataIC50:  0.480nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227786(8-{[Ethyl(methyl)amino]methyl}-4-[(2-fluoro-5-hydr...)
Affinity DataIC50:  0.487nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639321(Methyl 3-{[(5-chloro-2-thienyl)carbonyl]amino}-N-{...)
Affinity DataIC50:  0.490nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639349(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50:  0.490nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227807(US10047096, 69 | US10047096, 70 | US10047096, 71 |...)
Affinity DataIC50:  0.496nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227782(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(4...)
Affinity DataIC50:  0.498nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227929(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Affinity DataIC50:  0.503nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227925(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-(13...)
Affinity DataIC50:  0.503nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639349(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50:  0.510nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639346(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50:  0.520nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227830(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({3...)
Affinity DataIC50:  0.522nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227790(8-{[Butyl(ethyl)amino]methyl}-4-[(2-fluoro-5-hydro...)
Affinity DataIC50:  0.525nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639322(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-[...)
Affinity DataIC50:  0.540nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227795(BDBM227897 | US10047096, 58 | rac-4-[(2-Fluoro-5-h...)
Affinity DataIC50:  0.548nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639349(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50:  0.560nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227934(US10047096, 195 | trans-3-[({4-[(2-Fluoro-5-hydrox...)
Affinity DataIC50:  0.573nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227949(8-{[(3,4-cis-Dihydroxypyrrolidin-1-yl]methyl}-4-[(...)
Affinity DataIC50:  0.578nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227783(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-[(4...)
Affinity DataIC50:  0.580nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227789(8-{[Ethyl(2-hydroxyethyl)amino]methyl}-4-[(2-fluor...)
Affinity DataIC50:  0.582nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227793(8-[(4,4-Dimethylpiperidin-1-yl)methyl]-4-[(2-fluor...)
Affinity DataIC50:  0.595nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50327343(2-(4-(8-fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227947(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Affinity DataIC50:  0.601nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50:  0.610nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227826(8-(Aminomethyl)-4-[(2-fluoro-5-hydroxy-4-methylphe...)
Affinity DataIC50:  0.613nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227909(US10047096, 170 | US10047096, 171 | US10047096, 21...)
Affinity DataIC50:  0.618nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227930(US10047096, 191 | cis-Ethyl 3-[({4-[(2-fluoro-5-hy...)
Affinity DataIC50:  0.626nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639342(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-{[(5-chloro-2...)
Affinity DataIC50:  0.630nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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