Compile Data Set for Download or QSAR
maximum 50k data
Found 1448 with Last Name = 'banner' and Initial = 'd'
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037991(CHEMBL325166 | NAPSAGATRAN | Ro-46-6240 | {[(S)-3-...)
Affinity DataKi:  0.270nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM14714((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037976(CHEMBL341260 | {Benzyl-[(S)-3-[((S)-1-carbamimidoy...)
Affinity DataKi:  0.680nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037995(CHEMBL338669 | {[(S)-3-[((S)-1-Carbamimidoyl-piper...)
Affinity DataKi:  0.710nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037984(CHEMBL339094 | {Butyl-[(S)-3-[((S)-1-carbamimidoyl...)
Affinity DataKi:  0.860nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263570(CHEMBL4066422)
Affinity DataKi:  1nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263570(CHEMBL4066422)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13554((2S)-2-{2-[2-(benzenesulfonyl)-4-(benzyloxy)-5-met...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13554((2S)-2-{2-[2-(benzenesulfonyl)-4-(benzyloxy)-5-met...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263572(CHEMBL4092050)
Affinity DataKi:  2nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263577(CHEMBL4099651)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM210850(US9290467, 20)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263578(CHEMBL4064172)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM210854(US9290467, 24 | US9290467, 25 | US9290467, 26)
Affinity DataKi:  2.5nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295588(5-chloro-N-((3S,4S)-1-(2-(2-fluoro-4-(2-oxopyridin...)
Affinity DataKi:  3nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM210859(US9290467, 29)
Affinity DataKi:  3nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263571(CHEMBL4062591)
Affinity DataKi:  3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037983((2R,4R)-1-[(S)-3-[((S)-1-Carbamimidoyl-piperidin-3...)
Affinity DataKi:  3.10nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Oryctolagus cuniculus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324743((3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DIC...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to rabbit factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263569(CHEMBL4087751)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13552((2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13552((2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263574(CHEMBL4065847)
Affinity DataKi:  4.60nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037997((S)-4-Azocan-1-yl-N-(1-carbamimidoyl-piperidin-3-y...)
Affinity DataKi:  4.80nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263573(CHEMBL4080708)
Affinity DataKi:  4.80nMAssay Description:Agonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as RLuc8-fused Galphaq activation after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263573(CHEMBL4080708)
Affinity DataKi:  4.80nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263576(CHEMBL4072767)
Affinity DataKi:  5.20nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263584(CHEMBL4084294)
Affinity DataKi:  5.40nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263568(CHEMBL4098931)
Affinity DataKi:  5.60nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263583(CHEMBL4091192)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295581(4-chloro-N-(1-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-y...)
Affinity DataKi:  6nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295583(4-chloro-N-(1-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-y...)
Affinity DataKi:  6nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263569(CHEMBL4087751)
Affinity DataKi:  6.10nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037994((2R,4R)-1-[(S)-3-[((S)-1-Carbamimidoyl-piperidin-3...)
Affinity DataKi:  6.70nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13555((2S)-2-{2-[4-(benzyloxy)-5-methoxy-2-(2-phenylacet...)
Affinity DataKi:  7nM ΔG°:  -46.1kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13555((2S)-2-{2-[4-(benzyloxy)-5-methoxy-2-(2-phenylacet...)
Affinity DataKi:  7nM ΔG°:  -46.1kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263571(CHEMBL4062591)
Affinity DataKi:  7.30nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263584(CHEMBL4084294)
Affinity DataKi:  7.40nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324757((3R,4R)-N3-(4-chlorophenyl)-1-(N,N-dimethylsulfamo...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295585((R)-4-chloro-N-(1-(2-(2-fluoro-4-(2-oxopyridin-1(2...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324771((3R,4R)-N3-(5-chloropyridin-2-yl)-N4-(2-fluoro-4-(...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM36583(Tricyclic core, rac-20b)
Affinity DataKi:  8.10nMAssay Description:Enzyme inhibition assay using thrombin, a trypsin-like serine protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263568(CHEMBL4098931)
Affinity DataKi:  8.70nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324755((3R,4R)-N-(4-CHLOROPHENYL)-N'-[2-FLUORO-4-(2-OXOPY...)
Affinity DataKi:  9nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50037992((R)-N-((S)-1-Carbamimidoyl-piperidin-3-ylmethyl)-3...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity by measuring the inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Genentech

LigandPNGBDBM13592(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM36584(Tricyclic core, rac-20c)
Affinity DataKi:  10nMAssay Description:Enzyme inhibition assay using thrombin, a trypsin-like serine protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324758((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50295587(5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
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