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Found 35 with Last Name = 'bao' and Initial = 'h'
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50480722(CHEMBL373691)
Affinity DataKi:  310nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM23406((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Affinity DataIC50:  172nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by UV Vis- spectrophotometer analysisMore data for this Ligand-Target Pair
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610724(CHEMBL5280680)
Affinity DataIC50:  236nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by UV Vis- spectrophotometer analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019143(CHEMBL511275 | US10683309, Example LP533401)
Affinity DataIC50:  400nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495953(CHEMBL3121385)
Affinity DataIC50:  5.31E+3nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM225289(1,1''-bis(2-Fluorobenzyl)-[3,3':3'...)
Affinity DataIC50:  5.98E+3nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 1(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019142(CHEMBL3288777)
Affinity DataIC50:  6.22E+3nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610732(CHEMBL5281050)
Affinity DataIC50:  9.37E+3nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by UV based microplate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610731(CHEMBL4641347)
Affinity DataIC50:  9.46E+3nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by UV based microplate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495954(CHEMBL3121384)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610729(CHEMBL5268802)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by multimode plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610728(CHEMBL5266537)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by multimode plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610730(CHEMBL5266267)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by multimode plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610727(CHEMBL5286690)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by multimode plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610725(CHEMBL5281418)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by multimode plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))TBA
LigandPNGBDBM50610726(CHEMBL5282294)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of alpha glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate by multimode plate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 2(Rattus norvegicus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019142(CHEMBL3288777)
Affinity DataIC50:  4.55E+4nMAssay Description:Inhibition of TPH-2-mediated serotonin biosynthesis in rat PC12 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495956(CHEMBL223482 | PS-6130)
Affinity DataIC50:  5.67E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333127((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495957(CHEMBL3121492)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495955(CHEMBL3121493)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50495952(CHEMBL3121489)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase II subunit RPB1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333128(((2S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human RNA polymerase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333127((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase II subunit RPB1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human RNA polymerase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50:  5.50E+5nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50446691(CHEMBL3113623)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at human GPR119 incubated for 2 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50610733(CHEMBL5284750)
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at human GPR119 incubated for 2 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50019142(CHEMBL3288777)
Affinity DataKd:  6.82E+3nMAssay Description:Binding affinity to TPH-1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed