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Found 48 with Last Name = 'barberis' and Initial = 'a'
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataKi:  8.10E+3nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataKi:  9.40E+3nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataKi:  9.80E+3nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(1-(3-Acetyl-phenyl)-3-(3-ethylsulfanyl-[1,2,4]thia...)
Affinity DataKi:  2.88E+4nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50:  9nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50:  9nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  12nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  12nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(1-(3-Acetyl-phenyl)-3-(3-ethylsulfanyl-[1,2,4]thia...)
Affinity DataIC50: >25nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataIC50:  58nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataIC50:  97nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  120nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A5(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  120nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50090677(4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfon...)
Affinity DataIC50:  270nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetCytochrome P450 2C9(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50090677(4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfon...)
Affinity DataIC50:  270nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetCytochrome P450 2E1(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50110231(3-(3-Nitro-phenyl)-3-{2-[4-(pyridin-2-ylamino)-but...)
Affinity DataIC50:  850nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50010231(CHEMBL107217 | Ditiocarb sodium | Sodium salt of D...)
Affinity DataIC50:  850nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50236897(3-(furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H...)
Affinity DataIC50:  1.90E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50236897(3-(furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H...)
Affinity DataIC50:  1.90E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  3.50E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  3.50E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  5.00E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)
Affinity DataIC50:  5.00E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)
Affinity DataIC50:  6.90E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  6.90E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50:  9.20E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2E1(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50:  9.20E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A5(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50:  1.05E+4nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A5(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50:  1.05E+4nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50:  1.36E+4nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50:  1.36E+4nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50:  3.34E+4nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50:  3.34E+4nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50:  6.70E+4nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50:  6.70E+4nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50: >1.00E+5nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50: >1.00E+5nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM190404(US9180183, SC12)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50: >1.00E+5nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM189322(US9173935, SC12)
Affinity DataIC50: >1.00E+5nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataIC50:  2.84E+5nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataEC50:  23nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  3.5nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  2.70E+4nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1/2(Homo sapiens (Human))
University Of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(1-(3-Acetyl-phenyl)-3-(3-ethylsulfanyl-[1,2,4]thia...)
Affinity DataEC50:  11nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed